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Antiphospholipid Syndrome in Acute Cerebral Blood Flow Disorders

D. Minchev, L. Havezova, D. Georgieva


The purpose of the present study was to dynamically analyze the role of antiphospholipid syndrome in patients with acute disturbances of cerebral blood flow. Twenty-eight patients (16 females and 12 males) aged between 47 and 61 years were examined. The following criteria for patient's incorporation into the study were observed: presence of a focal neurological deficit, ultrasonographic evidence of disturbed cerebral blood flow, CT or MRI data about brain stroke. According to the data from the clinical or x-ray examination, the patients were divided into three groups: with hemorrhagic, embolic, or thrombotic stroke. Anticardiolipid (aCL) antibodies were assessed by ELISA method for a 12-month period. Elevated titres of aCL antibodies were proved in 12 patients (in 43 per cent of the cases) - in ten with ischemic and in two - with hemorrhagic stroke. The treatment with neuroprotective, antiaggregation and immunomodulatory means resulted in improvement of the clinical symptoms and antiphospholipid syndrome as well. It could be concluded that the summarized clinical, roentgenological and immunological data suggest the involvement of elevated titres of aCL antibodies into the pathogenesis of the acute cerebral blood flow disorders. The estimation of these antibodies should be considered obligatory in the patients with stroke with a view to enlargement of the prognostic criteria and more adequate therapeutic approach.


Antiphospoholipid Syndrome; Cerebral Blood Flow Disorders; Acute Stroke; Anticardiolipid Antibodies

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About The Authors

D. Minchev


D. Minchev, Dept. of Neurology, Prof. Paraskev Stoyanov Medical University of Varna, BG-9002 Varna 55 Marin Drinov St., Bulgaria

L. Havezova


D. Georgieva


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