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Assessment of the Subjective Visual Dysfunction of Patients With Multiple Sclerosis Using Specialized Questionnaires

A. Tsukeva, N. Deleva, I. Dimitrov, N. Usheva


Recently, the questions of the limited opportunities for measurement of the subjective and often subclinical visual dysfunction are very topical. NEI-VFQ, the questionnaire of the National Eye Institute in the USA and VFQ-25, its short version (25-item Vision Function Questionnaire) are validated for visual-specific assessment of the quality of life of multiple sclerosis (MS) patients. MSVQ-7, a specific 7-item MS Vision Questionnaire is proposed, too. The authors used the VFQ-25 translated into Bulgarian, the MSVQ-7 and their correlation with the binocular visual acuity. These questionnaires were administered to 108 MS patients without history of optic neuritis and after optic neuritis as well registered in the MS Centre in Varna and to 30 healthy subjects. There was a statistically significant difference (p<0,0001) between MS patients and controls in all sub-scales and in the overall results from VFQ-25. The analysis of MSVQ-7 showed a statistically significant difference between the answers of question Nos 1, 2, 3 and 5  p<0,001 to p=0,015). The correlation of the results from VFQ-25 and the binocular visual acuity was moderate (Spearman's r=0,6;  <0,01). The application of questionnaires for assessment of visual function may contribute to the identification of less known and sought subclinical visual dysfunctions that appear in normal visual acuity. Our data confirm the possible usage of VFQ-25 and MSVQ-7 for effective measurement of the subjective visual deficit in MS diagnosis.


Multiple Sclerosis; Visual Dysfunction

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About The Authors

A. Tsukeva


A. Tsukeva, Dept. of Neurology, Prof. Paraskev Stoyanov Medical University of Varna, BG-9002 Varna, 55 Marin Drinov St., Bulgaria

N. Deleva


I. Dimitrov


N. Usheva


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