Prevalence of comоrbidities in a cohort of patients with hemodynamically significant, pure aortic stenosis and sinus rhythm, admitted to cardiosurgery for a primary, isolated aortic valve replacement

Abstract

Once judged a degenerative disease, aortic valve stenosis is now believed to be very similar in terms of pathogenesis to atherosclerosis. This initial plaque of aortic stenosis is alike that of coronary artery disease. Risk factors associated with coronary artery disease - including age, male sex, hyperlipidaemia, and evidence of active inflammation - are held in common by the two disorders. Over the past decade a new hypothesis was coined, that comorbidities such as overweight/obesity, diabetes mellitus, chronic obstructive pulmonary disease, and salt-sensitive hypertension induce a systemic proinflammatory state wich, in turn, favours hypertrophy development. The latter contributes to high diastolic left ventricular stiffness and heart failure development. Comorbidities, along with other important biological markers, are proposed to be included in diagnostic algorithms. It is expected that comorbidities may have an important impact on the prognosis after aortic valve remplacement in patients with calcific aortic valve stenosis. In the current paper, we analyse the comorbidity profile amont patients with hemodynamically significant, pure aortic stenosis and sinus rhythm, admitted to cardiosurgery clinic for primary, isolated aortic valve replacement.Key words: aortic valve stenosis, aortic valve replacement, comorbidity