The differentiation of life-threatening dermatoses in newborn is of utmost importance. Infectious diseases, developmental defects and complicated genodermatoses are among the most important causes. Perinatal history, mother`s general state and epidemiologic data are the other important factors for the best verification and management. Herein, a thorough review of the most common life-threatening dermatoses in newborn, is presented. A diagnostic algorithm and therapeutic clues are provided.
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