According the published data concerning the problem Brain Metastases (BMs), the number of the patients with malignant diseases, also patients in the final IV stage (TNM) constantly and steadily increases, despite the tremendous and continuous advancement of the modern medicine. So, the adequate treatment of this group of population is an actual problem. At present the CT-Scan and MRI are standard for diagnostication of BMs, but they have little or no prognostic value for the effect that should be anticipated from the application of one or an other therapeutic approach (surgical treatment, radio therapy, chemotherapy). Single-Photon Emission Computed Tomography (SPECT) is a method of choice for evaluation of brain perfusion. Now it is well known that the brain perfusion is tightly coupled with the brain metabolism, respectfully with the brain function. With the present study we aim to evaluate with SPECT the brain perfusion of patients with BMs, also to reveal correlations with the extent of brain edema and with the quality of life of these patients. Demonstration of influence from the different therapeutic strategies to the brain perfusion could be used for optimization of the treatment of these patients.
Scripta Scientifica Medica, 2009; 41(2): 119-122.
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