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Cutaneous aspergillosis in a boy with acute leukemia: the lessons from a `simple` case

Milena Bozhkova, Temenuga Stoeva, Bonka Marinska, Valeria Kaleva, Deyan Dzhenkov, Igor Resnik


Fungal infections are among the most serious infectious complications in immunosuppressed patients. Primary cutaneous aspergillosis is a relatively rare manifestation and is usually described in patients with underlying malignant hematological diseases, AIDS, allogenic stem cell transplantation, solid organ transplantation, etc. We present a clinical case of a 12-year-old boy with acute lymphoblastic leukemia initially diagnosed as primary cutaneous aspergillosis caused by Aspergillus flavus. The retrospective analysis demonstrates that a small solitary pulmonary nodule could be a possible portal of entry. This means that we could consider the disease as an early stage invasive aspergillosis, which is successfully treated with voriconazole.


cutaneous aspergillosis, invasive aspergillosis, Aspergillus flavus, voriconazole

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About The Authors

Milena Bozhkova
Medical University of Varna Department of Microbiology and Virology

Temenuga Stoeva
Medical University of Varna Department of Microbiology and Virology

Bonka Marinska
Medical University of Varna Department of Pediatric Deseases

Valeria Kaleva
Medical University of Varna Department of Pediatric Deseases

Deyan Dzhenkov
Medical University of Varna Department of Clinical Pathology

Igor Resnik
Medical University of Varna

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