The significance of the endogenous factors in pathogenesis and natural history of urticaria is widely accepted. Chronic urticaria usually develops on the background of functional and organic disorders in various organs and systems. On the other hand, these disorders are predisposing factors for the genesis and development of the chronic urticaria. Thus, endogenous factors are considered to be pathogenic for urticaria. The aim of our study was to evaluate this two-way correlation of chronic urticaria and endogenous factors in 265 patients with different clinical forms of chronic urticaria. Clinical and paraclinical investigations, including allergologic tests (intradermal, scarification) were employed in order to establish association of chronic urticaria with gastrointestinal, hepatic, renal, endocrine, cardiovascular, neurological disorders, chronic infections, etc. The patients were divided in two separate groups: with chronic allergic (122) and non-allergic urticaria (143). The percentage of patients with urticaria associated with internal disorder was as follows: gastrointestinal 24,15%; hepatobiliary19,62%; endocrine 17,73%; urogenital 15,84%; cardiovascular 2,64%; chronic infections 3,01%; atopy 7,16%. Furthermore in the group of non-allergic urticaria 53,9% of the patients were with associated somatic disease, while in the group of allergic urticaria, the percentage was 46,1%. The same pattern of distribution was found in every group of the studied internal disorders. The results of the study show the significant prevalence of visceral diseases in the patients with chronic urticaria. The role of the endogenous factors in the pathogenesis of chronic urticaria is not well defined, but surely they are predisposing background on which various allergic and non-allergic pathogenic mechanisms super impose.
Scripta Scientifica Medica 2008;40(1):81-83
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