AMH (Anti-Müllerian Hormone, Müllerian Inhibiting Substance or Factor) is a member of the transforming growth factor - " family, secreted by the fetal and prepubertal testicular Sertoli cells, and to a lesser amount by the granulosa cells of the small ovarian follicles. It plays an important role in the shaping of the male reproductive tract and is one of the baseline hormones in the diagnostics of the disorders of the sex development in the male. In the female, in the recent years AMH has become an important clinical tool for evaluation of the ovarian follicular reserve, for predicting ovarian response to gonadotropin stimulation in IVF treatment and for the diagnosis of hyperandrogenism. Recombinant AMH is a promising medication for the treatment of gynecological cancers and endometriosis.
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