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Metabolic changes in experimental model of metabolic syndrome - induced by high-fructose diet in rats

Kameliya Bratoeva, Ganka Bekyarova, Yoana Kiselova, Maria Radanova, Diana Ivanova

Abstract

The global epidemic of metabolic syndrome (MS) correlates with changes in the environment, feeding, behavior and lifestyle, leading to obesity, glucose intolerans, dyslipidemia and elevated cardiovascular risk. AIM: The aim of our study was to develop an experimental model of the MS in rat that imitate the investigated metabolic disorders using high-fructose diet. METHODS: We used two groups: control group (C)- rats, maintained on plain water (n=6); fructose group (FRU)- rats received 12.5% high-fructose corn syrup in drinking water for 12 weeks (n=6). The main markers of metabolic abnormalities (glucose, total cholesterol, triglycerides, uric acid, body and organs weight), the markers of oxidative stress (malondialdehyde (MDA), total thiols) and C-reactive protein (CRP) - inflammatory marker were measured. RESULTS: Our data showed hypercholesterolemia, hyperglycemia, hyperuricemia and significant elevated levels of CRP, MDA, body and organs weight, and inhibited antioxidant defense in fructose- drinking rats. CONCLUSION: The experimental model will support our studies associated with pathophysiology and pharmacology of MS.


Keywords

experimental model of metabolic syndrome, fructose, liver, oxidative stress, rat

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DOI: http://dx.doi.org/10.14748/ssm.v42i4.8055
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About The Authors

Kameliya Bratoeva
Medical University of Varna
Bulgaria

Department of Pathophysiology

Ganka Bekyarova
Medical University of Varna
Bulgaria

Department of Pathophysiology

Yoana Kiselova
Medical University of Varna
Bulgaria

Department of Biochemistry, Molecular Medicine and
Nutrigenomics

Maria Radanova
Medical University of Varna
Bulgaria

Department of Biochemistry, Molecular Medicine and
Nutrigenomics

Diana Ivanova
Medical University of Varna
Bulgaria

Department of Biochemistry, Molecular Medicine and
Nutrigenomics

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