Introduction
We can now talk about predictive regenerative therapy thanks to the fact that there are a series of basic principles that, if taken into account, would guarantee the results we would like to achieve. These principles include primary wound closure, good angiogenesis, barrier function for the required period of time, ensuring and maintaining the space of the bone defect and keeping the blood clot stable.
Aim
The purpose of this review article is to present a general overview of the above-listed basic principles for achieving predictable results in regenerative therapy.
Materials and Methods
Keywords such as "regenerative therapy", "regenerative principles", "guided tissue regeneration", and "guided bone regeneration" were utilized to search Web of Science and Scopus for related scientific articles published in English up until 2024. The literature was thoroughly analyzed. After thoroughly reviewing the reference list, all papers were evaluated and examined for more relevant research.
Results
The basic principles that are necessary to achieve predictable regenerative outcomes are primary wound closure, good angiogenesis, barrier function for the required period of time, securing and maintaining the bone defect area, and keeping the blood clot stable.
Conclusion
Both a high degree of technical proficiency and a comprehensive understanding of the fundamentals of wound healing are necessary for a successful predictive regeneration.
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