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Effects of mulberry heartwood extract on genes related to lipid metabolism

Milena Pasheva, Milka Nashar, Oskan Tasinov, Diana Ivanova

Abstract

Scientific evidence exists that extracts from different parts of Morus nigra (mulberry tree), mainly fruits, leaves and root bark, exhibit various beneficial effects, such as antiviral, antihyperglycemic, antiatherogenic and hypotensive activity. Although it is known that the heartwood has a specific phytochemical composition, the biological effects of this part of the plant are not yet clarified. This study examines the effect of 40% ethanol infusion from mulberry heartwood on the expression of three genes related to lipid metabolism: CCAAT/enhancer binding protein-alpha (C/EBPα) gene, adipogenic transcriptional factors peroxisome proliferator-activated receptor gamma (PPARγ) and fatty acid-binding protein (aP2) genes in adipocytes. Results obtained present that treatment with two concentrations of mulberry ethanol extract decreased expression of aP2 messenger RNA as compared to controls. Based on these results we concluded that heartwood mulberry extract had beneficial effects on lipid metabolism and could be a potential source for search of active compounds for treatment of metabolic disorders related to adipose tissue metabolism.


Keywords

morus nigra; heartwood extract; adipocytes; gene expression; lipid metabolism

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References

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DOI: http://dx.doi.org/10.14748/ssp.v1i1.1084

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About The Authors

Milena Pasheva
Medical university of Varna

Department of Biochemistry, Molecular Medicine and Nutrigenomics

Milka Nashar
Medical university of Varna

Department of Biochemistry, Molecular Medicine and Nutrigenomics

Oskan Tasinov
Medical university of Varna

Department of Biochemistry, Molecular Medicine and Nutrigenomics

Diana Ivanova
Medical university of Varna

Department of Biochemistry, Molecular Medicine and Nutrigenomics

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