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Synthesis of n-alkylated derivatives of 1-(4-methoxyphenyl)-1,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-ones as potential anticonvulsants

Anna Severina, V. A. Georgiyants, S. Yu. Shtrygol, D. P. Kavraiskyi

Abstract

High psychotropic activity of pyrimidine derivatives attracts attention and directs the creation of new pyrimidine drugs which affect the central nervous system. As psychotropic agents a special attention deserve azolopyrimidine derivatives, including pyrazolopyrimidines.

Thus, among the pyrazolopyrimidine derivatives had been found compounds with antiepileptic, anticonvulsant, sedative, anxiolytic activity [1, 2], ligands of benzodiazepine site of GABA receptors [3]. In addition, the ligands of 5HT-6 receptors were identified that are promising for the treatment of central nervous system, muscle relaxants [4].

The purpose of this research was a synthesis of alkylated derivatives of 1-(4-methoxyphenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-ones.


Keywords

synthesis; pyrimidine; pyrazole; alkylation; acetamides, activity prediction

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References

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DOI: http://dx.doi.org/10.14748/ssp.v3i2.1408

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About The Authors

Anna Severina
National University of Pharmacy
Ukraine

V. A. Georgiyants
National University of Pharmacy
Ukraine

S. Yu. Shtrygol
National University of Pharmacy
Ukraine

D. P. Kavraiskyi
National University of Pharmacy
Ukraine

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