The study of physico-chemical and technological properties of active substances and their mixture for the development of a plant medicine with cardiotonic and immunomodulating action

Abstract

INTRODUCTION: To develop phytomedicine with a cardiotonic and immunomodulating effect in the form of hard gelatin capsules, to predict the rational composition and optimal technology for obtaining a combined medicine the determination of physico-chemical and pharmaco-technological properties of the lyophilized sunflower protein substance, the dry extract of hawthorn flowers and fruits and the mixture of these biologically active substances in the ratio 1.4: 1 have been  used.

MATERIALS AND METHODS: Physical and technological methods on State Pharmacopoeia of Ukraine

2.0 have been used.

RESULTS: The results of the studies of microscopy, bulk volume, settled volume, settling qualities, bulk density, tapped density, flowability, angle of repose and moisture absorption of the lyophilized sunflower protein substance, the dry hawthorn extract and their mixture were  analyzed.

The extract does not have flowability because of the fineness of the powder and rough surface of particles.    It was necessary to grind additionally the protein substance to achieve the homogeneity of the mixture of  the two active substances. The re-milled protein substance showed good flowability. But the flow rate of the mixture was lower. The mixture of powders was characterized by the low bulk density and tapped density, a significant settling quality of the mixture.

CONCLUSION: Analyses of the data obtained pointed to the need to additionally grind the lyophilized sunflower protein substance and to introduce glidants into the mass for the incapsulation, or the obtaining granules. Moisture regulators must be added to the composition for the incapsulation because of the signif- icant moisture absorption of the powder  mixture.