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Debunking Chemiosmosis and Proposing Murburn Concept as the Operative Principle for Cellular Respiration

Kelath Murali Manoj


During cellular respiration, aerobic eukaryotes employ molecular oxygen within the mitochondria, to generate the energy currency of ATP. Chemiosmosis, the long-standing mechanism of mitochondrial oxidative redox metabolism, vouches for the “harnessing of a trans-membrane proton potential” for the synthesis of ATP. Herein, select elements of the chemiosmosis proposal are critically reviewed and debunked. Further, based on simple analogies and structurefunction correlations, murburn concept (connoting to "mured burning” or mild unrestricted burning), the recently established mechanism for microsomal xenobiotic metabolism, is advocated as a probable molecular explanation for mitochondrial oxidative phosphorylation. It is envisaged that the stochastic mechanism of murburn concept could play pivotal roles in several biological redox schemes. The concept necessitates a paradigm shift in mitochondrial biochemistry. Biomed Rev 2017; 28: 31-48.


Keywords: murburn concept, cellular respiration, mitochondrial oxidative phosphorylation, microsomal xenobiotic metabolism, ATP synthesis, chemiosmosis, reactive oxygen species

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About The Author

Kelath Murali Manoj
Satyamjayatu: The Science and Ethics Foundation, Kulappully, Shoranur-2 (PO), Palakkad District, Kerala

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