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Annual for Hospital Pharmacy

Historical Review And Analysis Of Contemporary Aspects In The Treatment Of Acute And Chronic Form Of Q-Fever

Metodi Kunchev, Ivanka Gergova, Virsavia Vaseva, Evgeni Grigorov


Worldwide spread Q-fever zoonosis is caused by the intracellular microorganism Coxiella burnetii. The disease is endemic to our country and has both acute and chronic forms. Due to the non-specific symptoms of Q-fever, accurate diagnosis and proper treatment are difficult. Historically, the treatment of the disease has undergone many changes associated with various in vitro models for studying the sensitivity of Coxiella burnetii to antibiotic combinations. For acute treatment of the acute form of Q-fever in adults, 100 mg doxycycline is used twice daily for 14 days, and co-trimoxazole (trimethoprim/sulfamethoxazole: 160mg/800mg) twice daily during pregnancy is recommended up to the last six weeks of pregnancy. Current chronic disease therapy includes 100 mg doxycycline twice daily combined with hydroxychloroquine three times a day at 200 mg per dose for at least 18 months.


Q-fever, disease, treatment

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