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Transmission mechanism in COVID-19 and the management of the epidemic process

Rumen Konstantinov


The health significance, determined by the severity of the clinical course, the mass systemic nature of the epidemic process and the high intensity of coverage of the population worldwide, posed to epidemiological science the problem of studying and clarifying the peculiarities of the epidemic process in COVID-19 and its management. In this epidemiological study, we set out to examine the mechanisms and routes of transmission of SARS-CoV-2 in human society and the possibilities for managing the epidemic process. Theoretical and epidemiological methods, analysis and prognosis were used. A theoretical-epidemiological and applied analysis of the peculiarities of the process of the transmission mechanism in COVID-19 has been performed and the specific practical directions for the effective and rational anti-epidemic behavior are indicated.


mechanisms and routes of transmission in SARS-CoV-2, epidemic process management, SARS-CoV-2, faecal-oral transmission mechanism, oral vaccine

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Горенков Д.В., Хантимирова Л.М., Шевцов В.А., и др. Вспышка нового инфекционного заболевания COVID-19: β-коронавирусы как угроза глобальному здравоохранению // Биопрепараты. Профилактика, Диагностика, Лечение. 2020. № 1 (20). C. 6–20.

Громашевский Л.В. Механизм передачи инфекции / Громашевский Л.В., Киев:, 1962. 435 c.

Громашевский Л.В. Общая эпидемиология / Громашевский Л.В., Москва: Медицина, 1965. 289 c.

Константинов Р. Теоретични и приложни аспекти на съвременната епидемиология , Варна, СТЕНО, 2018. 308 c.

Львов Д.К., Альховский С.В., Колобухина Л.В., и др. Этиология Эпидемической Вспышки Covid-19 В Г. Ухань (провинция Хубэй, Китайская Народная Республика), Ассоциированной С Вирусом 2019-Ncov (nidovirales, Coronaviridae, Coronavirinae, Betacoronavirus, Подрод Sarbecovirus): Уроки Эпидемии Sars-Cov // Вопросы Вирусологии. 2020. № 1 (65). C. 6–15.

Никифоров В.В., Суранова Т.Г., Миронов А.Ю., и др. Новая коронавирусная инфекция (COVID-19): этиология, эпидемиология,клиника, диагностика, лечение и профилактика / В.В. Никифоров, Т.Г. Суранова, А.Ю. Миронов, Ф.Г. Забозлаев, Академия постдипломного образования ФГБУ «ФНКЦ ФМБА России»,.

Прилуцкий А.С. Коронавирусная Болезнь 2019. Часть 1: Характеристика Коронавируса, Эпидемиологические Особенности // Вестник Гигиены И Эпидемиологии. 2020. № 1 (24). C. 77–86.

Прилуцкий А.С. Коронавирусная Болезнь 2019. Часть 2: Клиника, Диагностика, Лечение, Профилактика // Вестник Гигиены И Эпидемиологии. 2020. № 1 (24). C. 87–101.

Романов Б.К. Коронавирусная инфекция COVID-2019 // Безопасность И Риск Фармакотерапии. 2020. № 1 (8). C. 3–8.

Borghesi A., Aggiusti C., Farina D., и др. COVID-19 Pneumonia: Three Thoracic Complications in the Same Patient // Diagnostics. 2020.

Bruno Heberto A., Corona Juan Carlos P., Rubio José Antonio C., и др. ¨ IMPLICATIONS OF MYOCARDIAL INJURY IN MEXICAN HOSPITALIZED PATIENTS WITH CORONAVIRUS DISEASE 2019 (COVID-19). // Int J Cardiol Heart Vasc. 2020. C. 100638–100638.

Costanzo L., Failla G., Grasso S.A., и др. COVID-19 pneumonia: The impact of coagulopathy // Acta Phleool. 2020. № 21 (1–2). C. 6–8.

Dietz L., Horve P.F., Coil D.A., и др. 2019 Novel Coronavirus (COVID-19) Pandemic: Built Environment Considerations To Reduce Transmission // mSystems. 2020. № 2 (5).

Elsamadony M., Fujii M., Miura T., и др. Possible transmission of viruses from contaminated human feces and sewage: Implications for SARS-CoV-2. // Sci Total Environ. 2020. № Pt 1 (755). C. 142575–142575.

Fang Y., Zhou J., Ding X., и др. Pulmonary fibrosis in critical ill patients recovered from COVID-19 pneumonia: Preliminary experience // The American Journal of Emergency Medicine. 2020.

Johnson K.D., Harris C., Cain J.K., и др. Pulmonary and Extra-Pulmonary Clinical Manifestations of COVID-19 // Front. Med. 2020. № 7.

Kayhan S., Kocakoç E. Pulmonary Fibrosis Due to COVID-19 Pneumonia. // Korean J Radiol. 2020. № 11 (21). C. 1273–1275.

Konstantinov R. COVID 19 – произход, епидемиологичен анализ и прогноза // Социална медицина. 2019. № 2. C. 2–8.

Li L.-Q., Huang T., Wang Y.-Q., и др. 2019 novel coronavirus patients’ clinical characteristics, discharge rate and fatality rate of meta-analysis // Journal of medical virology. 2020. C. 10.1002/jmv.25757-10.1002/jmv.25757.

Liu P., Tan X.-Z. 2019 Novel Coronavirus (2019-nCoV) Pneumonia // Radiology. 2020. C. 200257–200257.

Mesoraca A., Margiotti K., Viola A., и др. Evaluation of SARS-CoV-2 viral RNA in fecal samples. // Virol J. 2020. № 1 (17). C. 86–86.

Mohan N., Deswal S. Corona Virus Disease (COVID-19) Fecal-oral transmission: Is it a potential risk for Indians? // Indian J Gastroenterol. 2020. № 3 (39). C. 305–306.

Mussig K. Corona pandemic: Obesity increases risk of severe course of COVID-19. [German] // MMW-Fortschritte der Medizin. 2020.

Noh J., Chang H.H., Jeong I.K., и др. Coronavirus Disease 2019 and Diabetes: The Epidemic and the Korean Diabetes Association Perspective. // Diabetes Metab J. 2020. № 3 (44). C. 372–381.

Ojo A.S., Balogun S.A., Williams O.T., и др. Pulmonary Fibrosis in COVID-19 Survivors: Predictive Factors and Risk Reduction Strategies. // Pulm Med. 2020. (2020). C. 6175964–6175964.

Shah A., Kashyap R., Tosh P., и др. Guide to Understanding the 2019 Novel Coronavirus // Mayo Clinic Proceedings. 2020.

Shi F., Yu Q., Huang W., и др. 2019 Novel Coronavirus (COVID-19) Pneumonia with Hemoptysis as the Initial Symptom: CT and Clinical Features 2020.

Shirani K., Toghyani A. COVID-19 pneumonia with scant respiratory symptoms // Journal of Research in Medical Sciences. 2020.

Singhania N., Bansal S., Nimmatoori D.P., и др. Current Overview on Hypercoagulability in COVID-19. // Am. j. cardiovasc. drugs. 2020.

Thomas-Rüddel D., Winning J., Dickmann P., и др. „Coronavirus disease 2019“ (COVID-19): update für Anästhesisten und Intensivmediziner März 2020 // Der Anaesthesist. 2020. C. 1–11.

Tian Y., Rong L., Nian W., и др. Review article: gastrointestinal features in COVID-19 and the possibility of faecal transmission. // Aliment Pharmacol Ther. 2020. № 9 (51). C. 843–851.

Vasarmidi E., Tsitoura E., Spandidos D.A., и др. Pulmonary fibrosis in the aftermath of the COVID-19 era (Review). // Exp Ther Med. 2020. № 3 (20). C. 2557–2560.

Vella F., Senia P., Ceccarelli M., и др. Transmission mode associated with coronavirus disease 2019: a review. // Eur Rev Med Pharmacol Sci. 2020. № 14 (24). C. 7889–7904.

Wei J., Xu H., Xiong J., и др. 2019 Novel Coronavirus (COVID-19) Pneumonia: Serial Computer Tomography Findings // Korean journal of radiology. 2020.

YAN J., LI M., SUN A., и др. 2019 novel coronavirus (2019-nCoV) and 2019-nCoV pneumonia // Chinese Journal of Microbiology and Immunology. 2020. № 0 (40). C. E001–E001.

Zhou H., Chen X., Hu T., и др. A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein // Current Biology. 2020.

Zhou J., Li C., Liu X., и др. Infection of bat and human intestinal organoids by SARS-CoV-2 // Nature Medicine. 2020. № 7 (26). C. 1077–1083.

WHO Coronavirus Disease (COVID-19) Dashboard [Электронный ресурс]. URL: (дата обращения: 16.10.2020).



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