The nutritional status of children with neurodevelopmental disorders (NDDs) has a significant impact on their overall health and quality of life. Most of the scientific research, exploring NDD children`s nutrition, has been dedicated to cerebral palsy (CP) patients who are reported to suffer from malnutrition in 46% - 90% of the cases. The etiology of malnutrition in children with NDD involves many underlying factors and can be contributed to both nutritional and non-nutritional factors. Obesity typically associated with mentally retarded children and children with genetic syndromes (e.g. Down syndrome) is nowadays less frequently observed. The energy needs of children with severe cases of central nervous system disorder differ from the energy requirements of normally developing children. The difference can be largely attributed to the interplay of several factors affecting the basal metabolic rate. The prevalence of malnutrition can induce or worsen respiratory failure as well as secondary immune deficiency, which in turn affects the prognosis of the underlying disease. Macronutrient deficiency in NDD children is commonly accompanied by micronutrient losses of folate, iron, magnesium, vitamin D, essential fatty acids, etc., which are crucial for a number of metabolic pathways. The lacking in any or all macro- and micronutrients may produce symptoms that are difficult to distinguish from the already present neurological disorder. This situation calls for a comprehensive evaluation and nutritional support for NDD children for an improved prognosis and quality of life, considering the current data and knowledge on the problem.
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