Introduction: The COVID-19 pandemic has increased the risk of antibiotic resistance around the world.
Aim: The study’s goal is to investigate the impact of the COVID-19 epidemic on antibiotic use in Bulgaria.
Materials and Methods: A comparative study from reports of the European Centre for Disease Prevention and Control (ECDC) of the nation's antibiotic use and level of antibiotic resistance for the years 2018–2022. An online survey was conducted in September 2022 among citizens who had been diagnosed with COVID-19 through social media using Google Forms. A total number of 213 respondents participated in the survey.
Results: During the pandemic, antibiotics were used more frequently in hospital and outpatient settings compared to previous years. The greatest increase was observed in outpatient settings according to ECDC data. Almost half of the respondents (49.8%) were prescribed an antibiotic as a treatment for COVID-19 based on the attending physician’s judgment. A total of 60.4% of the patients were recommended antibiotic treatment without a preliminary laboratory test. Almost all patients (94.4%) who were prescribed an antibiotic purchased it. For 43.6% of them, therapy was prescribed over the phone. Antibiotic therapy was mostly recommended by general practitioners (80.4%).
Conclusion: The COVID-19 pandemic has increased the use of antibiotics in Bulgaria.
World Health Organization. Global action plan on antimicrobial resistance [Internet]. Geneva: World Health Organization; 2016 [cited 2023 July 8]. Available from: https://www.who.int/publications/i/item/9789241509763
World Health Organization Regional Office for Europe. EUR/RC61/14. Regional Action Plan on Antibiotic Resistance. Sixty-first session of the Regional Committee for Europe [Internet]. Copenhagen; WHO Regional Office for Europe;2011 [cited 2023 July 11]. Available from: https://www.euro.who.int/en/about-us/governance/regional-committee-for-europe/past-sessions/sixty-first-session/documentation/working-documents/wd14-european-strategic-action-plan-on-antibiotic-resistance
European Commission, European Health and Digital Executive Agency, Dates, M., Davies, M., Kobilsky, A. et al. Study on the barriers to effective development and implementation of national policies on antimicrobial resistance – Final report [Internet]: Publications Office of the European Union; 2023 [cited 2024 February 14]. Available from: https://op.europa.eu/en/publication-detail/-/publication/8e6eeab8-4ba3-11ee-9220-01aa75ed71a1/language-en
European Centre for Disease Prevention and Control. Assessing the health burden of infections with antibiotic-resistant bacteria in the EU/EEA, 2016-2020 [Internet]. Stockholm: ECDC; 2022 [cited 2023 July 6]. Available from: https://www.ecdc.europa.eu/en/publications-data/health-burden-infections-antibiotic-resistant-bacteria-2016-2020
European Centre for Disease Prevention and Control (ECDC). Antimicrobial resistance in the EU/EEA (EARS-Net), Annual Epidemiological Report for 2022 [Internet]. Stockholm: ECDC; 2023 [cited 2023 November 1]. Available from: https://www.ecdc.europa.eu/en/publications-data/surveillance-antimicrobial-resistance-europe-2022
Shi H, Han X, Jiang N, Cao Y, Alwalid O, Gu J, et al. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Lancet Infect Dis [Internet]. 2020 Feb [cited 2023 October 15];20(4):425-434. Available from: https://pubmed.ncbi.nlm.nih.gov/32105637/
Kalil AC. Treating COVID-19-Off-label drug use, compassionate use, and randomized clinical trials during pandemics. JAMA [Internet]. 2020 May [cited 2023 October 2]; 19;323(19):1897-1898. Available from: https://jamanetwork.com/journals/jama/fullarticle/2763802
Langford BJ, So M, Raybardhan S, Leung V, Westwood D, MacFadden DR, et al. Bacterial co-infection and secondary infection in patients with COVID-19: a living rapid review and meta-analysis. Clin Microbiol Infect [Internet]. 2020 Dec [cited 2023 October 2];26(12):1622-1629. Available from: https://www.sciencedirect.com/science/article/pii/S1198743X20304237?via%3Dihub
Rawson TM, Moore LSP, Zhu N, Ranganathan N, Skolimowska K, Gilchrist M, et al. Bacterial and fungal co-infection in individuals with coronavirus: a rapid review to support COVID-19 antimicrobial prescribing. Clin Infect Dis [Internet]. 2020 Dec [cited 2023 July 3]; 71(9):2459-2468. Available from: https://academic.oup.com/cid/article/71/9/2459/5828058?login=true
Clancy CJ, Buehrle DJ, Nguyen MH. PRO: The COVID-19 pandemic will result in increased antimicrobial resistance rates. JAC Antimicrob Resist [Internet]. 2020 Sep [cited 2023 July 11];2(3):dlaa049. Available from: https://academic.oup.com/jacamr/article/2/3/dlaa049/5872561?login=true
Breaking Results: Sermo’s COVID-19 Real Time Barometer Study [Internet]. [cited 2023 June 21]. Available from https://public-cdn.sermo.com/covid19/c8/be4e/4edbd4/dbd4ba4ac5a3b3d9a479f99cc5/wave-i-sermo-covid-19-global-analysis-final.pdf
European Centre for Disease Prevention and Control. Antimicrobial consumption in the EU/EEA (EARS-Net) - Annual Epidemiological Report for 2022 [Internet]. Stockholm: ECDC;2023 [cited 2023 August 21]. Available from: https://www.ecdc.europa.eu/en/publications-data/surveillance-antimicrobial-consumption-europe-2022#:~:text=The%202022%20EU%20population%2Dweighted,range%3A%209.1%E2%80%9333.5).
Vankova D, Kapincheva I, Micheva I, Boncheva P, Mihaylova S, Kanalev R, et al. One Health strategies for addressing antimicrobial resistance: an exclusive emphasis on Bulgaria. Eur J Public Health [Internet]. 2023 Oct [cited 2024 February 11]:24;33(Suppl 2):ckad160. Available from: https://academic.oup.com/eurpub/article/33/Supplement_2/ckad160.1026/7327851
European Antimicrobial Resistance Collaborators.The burden of bacterial antimicrobial resistance in the WHO European region in 2019: a cross‑country systematic analysis. The Lancet Public Health [Internet]. 2022 Nov [cited 2023 November 11];e897–e913. Available from: https://www.sciencedirect.com/science/article/pii/S2468266722002250?via%3Dihub
Bulgarian National Radio [Internet]. Associate Professor Ivan Ivanov: The use of antibiotics in our country has increased dramatically. Bulgarian National Radio;2021 [cited 2023 September 6] Available from: https://bnr.bg/post/101559178.
World Health Organization [Internet]. 2021 AWaRe classification. World Health Organization: Geneva [cited 2023 September 11]. Available from: https://www.who.int/publications/i/item/2021-aware-classification
Ministry of Health. Order №RD-01-124/13.03.2020.
Ministry of Health. The emergency epidemiological situation ended on April 1;2022. Available from: https://www.mh.government.bg/bg/novini/aktualno/ot-1-april-otpada-izvnrednata-epidemichna-obstanov/
European Union. Special Eurobarometer 522 “Antimicrobial Resistance”. Country Factsheets Bulgaria [Internet]; 2022 [cited 2024 February 17]. Available from: https://europa.eu/eurobarometer/surveys/detail/2632
Zaykova K, Nikolova S, Pancheva R, Serbezova A. A survey of knowledge, attitudes and use of antibiotics among Bulgarian population.Biotechnology & Biotechnological Equipment [Internet]. 2022 [cited 2024 February 17]. Available from: https://www.tandfonline.com/doi/full/10.1080/13102818.2022.2145237