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Varna Medical Forum

Analysis of Staphylococcus aureus Carriage Among Students at Varna Medical University

Radka Stoyanova, Mira Popova, Krasimira Karakoleva, Teodora Katrandzhieva, Tatina Todorova

Abstract

Introduction: Staphylococcus aureus is one of the most common causes of nosocomial infections. The main sources of transmission are hospital staff and contaminated hands.

Aim: The current study presents data on nasal colonization among medical students undergoing training in high-risk hospital departments.

Materials and Methods: We analyzed 253 nasal and 241 throat secretion samples from medical students who opted to be examined in the Laboratory of Microbiology at St. Marina University Hospital in Varna during the period 2021–2023. The samples were cultured on blood agar, and Staphylococcus aureus was identified using standard biochemical tests. Statistical analysis was performed using R Project software (version 4.0.4/2021-02-15).

Results: Only 15.8% of nasal secretion samples tested positive for Staphylococcus aureus. Positive throat samples were almost negligible, accounting for only 1.2%. The proportion of positive women was higher, but the difference was not statistically significant (17.3% vs. 14% of men; χ² = 0.5 and p-value = 0.5). No statistically significant difference was observed in the number of positive samples across different age groups.

Conclusion: Despite the low carriage rate observed, screening for nasal colonization can help reduce the risk of nosocomial transmission.

Keywords

S. aureus, carriage, medical students

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References

Ansari S, Gautam R, Shrestha S, Ansari SR, Subedi SN, Chhetri MR. Risk factors assessment for nasal colonization of Staphylococcus aureus and its methicillin resistant strains among pre-clinical medical students of Nepal. BMC Res Notes. 2016;9:214.

Corey GR. Staphylococcus aureus bloodstream infections: definitions and treatment. Clin Infect Dis. 2009;48:S254–9.

Kubica M, Guzik K, Koziel J, Zarebski М, Richter W, Gajkowska B, et al. A potential new pathway for Staphylococcus aureus dissemination: the silent survival of S. aureus phagocytosed by human monocyte-derived macrophages. PLoS One. 2008;3:e1409.

Lowy FD. Staphylococcus aureus infections. N Engl J Med. 1998;339(8):520-32

Raineri EJM, Altulea D, van Dijl JM. Staphylococcal trafficking and infection – from 'nose to gut' and back. FEMS Microbiol Rev. 2022;46(1):fuab041.

Rasigade J-P, Dumitrescu O, Lina G. New epidemiology of Staphylococcus aureus infections. Clin Microbiol Infect. 2014;20(7):587-8.

Sakr A, Brégeon F, Mège JL, Rolain JM, Blin O. Staphylococcus aureus Nasal Colonization: An Update on Mechanisms, Epidemiology, Risk Factors, and Subsequent Infections. Front Microbiol. 2018;9:2419.

Solberg CO. Spread of Staphylococcus aureus in hospitals: causes and prevention. Scand J Infect Dis. 2000;32(6):587-95.

Taylor TA, Unakal CG. Staphylococcus aureus Infection. [Updated 2023 Jul 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK441868/.

Tong SY, Davis JS, Eichenberger E, Holland TL, Fowler VG. Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management. Clin Microbiol Rev. 2015;28(3):603-61.

Wertheim HFL, Melles DC, Vos MC, van Leeuwen W, van Belkum A, Verbrugh HA, et al. The role of nasal carriage in Staphylococcus aureus infections. Lancet Infect Dis. 2005;5:751–62.




DOI: http://dx.doi.org/10.14748/vmf.v13i1.10177

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