Scientific Online Resource System

Varna Medical Forum

Biological Aspects of in Vitro Fertilization in Patients with Poor Ovarian Reserve

Gergana Ingilizova, Ivan Kostov, Ivan Lazarov, Daniela Velkova

Abstract

Poor ovarian response to a controlled ovarian hyperstimulation (ÑÎÍ) results, usually, in a reduced follicular response which leads to a diminished number of retrieved oocytes. The low ovarian reserve is defined by the following characteristics: i) older patients or patients with another risk factor leading to low ovarian reserve, ii) previous poor ovarian response, and iii) deviation from the normal levels of the examined ovarian reserve. The aim of the present survey is to review the literature data about the influence of the poor ovarian response on the quantity and quality of the retrieved oocytes and preimplantational embryos during IVF/ICS cycles in a particular group of patients as well as to highlight future directions for procedures and research in this field in order to elaborate prognostic criteria for the assessment of procedural outcome of assisted reproduction and for the improvement of the results from a biological viewpoint.

Keywords

low ovarian reserve; poor ovarian response; oocytes, embryos; in vitro fertilization

Full Text


References

Bancsi, L. F., F. J. Broekmans, M. J. Eijkemans, et al. Predictors of poor ovarian response in in vitro fertilization: a prospective study comparing basal markers of ovarian reserve.- Fertil. Steril., 77, 2002, No 2, 328-336.

Bartmann, A. K., F. M. Araujo, O. Iannetta, et al. Down syndrome and precocious menopause.- J. Assist. Reprod. Genet., 22, 2005, No 3, 129-131.

Gleicher, N., D. H. Barad. Dehydroepiandrosterone (DHEA) supplementation in diminished ovarian reserve (DOR).- Reprod. Biol. Endocrinol., 9, 2011, 67. doi: 10.1186/1477-7827-9-67.

Haadsma, M. L., T. M. Mooij, H. Groen, et al. A reduced size of the ovarian follicle pool is associated with an increased risk of a trisomic pregnancy in IVF-treated women.- Hum. Reprod., 25, 2010, No 2, 552-558.

Kumbak, B., S. Kahraman, G. Karlikava, et al. In vitro fertilization in normoresponder patients with endometriomas: comparison with basal simple ovarian cysts.- Gynecol. Obstet. Invest., 65, 2008, No 3, 212-216.

Levi, A. J., M. F. Raynault, P. A. Bergh, et al. Reproductive outcome in patients with diminished ovarian reserve.- Fertil. Steril., 76, 2001, No 4, 666-669.

May-Panloup, P., M. F. Chrétien, C. Jacques, et al. Low oocyte mitochondrial DNA content in ovarian insufficiency.- Hum. Reprod., 20, 2005, No 3, 593-597.

Moreno, C., A. Ruiz, C. Simón, et al. Intracytoplasmic sperm injection as a routine indication in low responder patients.- Hum. Reprod., 13, 1998, No 8, 2126-2129.

Nichi, M., R. de Cassia Sávio Figueira, D. Paes de Almeida Ferreira Braga, et al. Decreased fertility in poor responder women is not related to oocyte morphological status.- Arch. Med. Sci., 7, 2011, No 2, 315-320.

Schimberni, M., F. Morgia, J. Colabianchi, et al. Natural-cycle in vitro fertilization in poor responder patients: a survey of 500 consecutive cycles.- Fertil. Steril., 92, 2008, No 4, 1297-1301.

Setti, A. S., D. P. de Almeida Ferreira Braga, R. de Cássia Savio Figueira, et al. Are poor responders patients at higher risk for producing aneuploid embryos in vitro?- J. Assist. Reprod. Genet., 28, 2011, No 5, 399-404.

Smeenk, J. M., F. C. Sweep, G. A. Zielhuis, et al. Antimüllerian hormone predicts ovarian responsiveness, but not embryo quality or pregnancy, after in vitro fertilization or intracyoplasmic sperm injection.- Fertil. Steril., 87, 2007, No 1, 223-226.

Toner, J. P. Ovarian reserve, female age a nd the chance for successful pregnancy.- Minerva Ginecol., 55, 2003, No 5, 399-406.

Thum, M. Y., H. I. Abdalla, D. Taylor. Relationship between women`s age and basal follicle-stimulating hormone levels with aneuploidy risk in in vitro fertilization treatment.- Fertil. Steril., 90, 2008, No 2, 315-321.

Weghofer, A., D. Barad, J. Li J, et al. Aneuploidy rates in embryos from women with prematurely declining ovarian function: a pilot study.- Fertil. Steril., 88, 2007, No 1, 90-94.




DOI: http://dx.doi.org/10.14748/vmf.v2i2.1094

Refbacks

User Guide

Font Size


|