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Varna Medical Forum

Epileptic seizures in patients with acute stroke

Mihael Tsalta-Mladenov, Vladina Dimitrova, Darina Georgieva, Silva Andonova

Abstract

Stroke is the most common cause of epileptic seizures in middle-aged and elderly patients. The incidence of epileptic seizures depends on several factors, as the most important of them are the type and severity of stroke, the etiopathogenesis and the presence of electroencephalographic (EEG) changes.

Subject of our study are a total of 1156 patients with acute stroke, hospitalized at the Second Neurological Clinic with ICU and Stroke Unit of St. Marina University Hospital, Varna for the period from January 2017 to December 2017.

The results from our study are largely correlated with those reported in the scientific literature from previous studies. The incidence of seizures after stroke is 5.81 percent, with more frequent seizures after hemorrhagic stroke. In the group with ischemic stroke, there is a higher incidence of thrombotic than embolic etiopathogenesis. According to the gender distribution, there is an increased risk of seizures after stroke in men. The severity of stroke assessed using the NIHSS scale, correlates with the incidence of seizures, as 80% of patients are rated with moderate or severe neurological impairment, and this serves as major predictor of epileptic seizures after a stroke.


Keywords

Мозъчен инсулт, Епилепсия, Пристъпи

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References

Националния консенсус за диагностика и лечение на епилепсия, сп. Българска Неврологя, том 17, бр. 2, доп 2, 2016

Alexander E. Merkler et al., Population-Based Assessment of the Long-Term Risk of Seizures in Survivors of Stroke, Stroke. 2018 Jun;49(6):1319-1324.

Bladin C, Alexandrov A, Norris JW (1998). Post-stroke epilepsy. In: H Markus, M Brown, L Kaira, G Turpie, C Wolfe (Eds.), Current Medical Literature. London.

Bladin C., Alexandrov A., Bellavance A., Bornstein N., Chambers B., Cote R., et al. (2000) Seizures after stroke: a prospective multicenter study. Arch Neurol 57: 1617-1622

Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Engel J Jr, Forsgren L, French JA, Glynn M, Hesdorffer DC, Lee BI, Mathern GW, Moshé SL, Perucca E, Scheffer IE, Tomson T, Watanabe M, Wiebe S., ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014 Apr;55(4):475-82. doi: 10.1111/epi.12550. Epub 2014 Apr 14.

Forsgren L., Beghi E., Oun A., Sillanpaa M. (2005) The epidemiology of epilepsy in europe - a systematic review. Eur J Neurol 12: 245-253

Graham N., Crichton S., Koutroumanidis M., Wolfe C., Rudd A. (2013) Incidence and associations of poststroke epilepsy: the prospective south London stroke register. Stroke 44: 605-611

Jungehulsing G., Heuschmann P., Holtkamp M., Schwab S., Kolominsky-Rabas P. (2013) Incidence and predictors of post-stroke epilepsy. Acta Neurol Scand 127: 427-430

Kammersgaard L., Olsen T. (2005) Poststroke epilepsy in the Copenhagen Stroke Study: incidence and predictors. J Stroke Cerebrovasc Dis 14: 210-214

Kraus JA, Berlit P (1998). Cerebral embolism and epileptic seizures-the role of the embolic source. Acta Neurol Scand 97: 154-158.

Labovitz D., Hauser W., Sacco R. (2001) Prevalence and predictors of early seizure and status epilepticus after first stroke. Neurology 57: 200-206

Loscher W., Hirsch L., Schmidt D. (2015) The enigma of the latent period in the development of symptomatic acquired epilepsy - traditional view versus new concepts. Epilepsy Behav 52: 78-92.

Pezzini A., Grassi M., Del Zotto E., Giossi A., Volonghi I., Costa P., et al. (2013) Complications of acute stroke and the occurrence of early seizures. Cerebrovasc Dis 35: 444-450.

Pitkanen A., Roivainen R., Lukasiuk K. (2015) Development of epilepsy after ischaemic stroke. Lancet Neurol pii: S1474-4422 (15) 00248-3.

Richardson EP, Dodge PR (1954). Epilepsy in cerebral vascular disease; a study of the incidence and nature of seizures in 104 consecutive autopsy-proven cases of cerebral infarction or hemorrhage. Epilepsia 3: 49-74.

Safeng Zou, Xiaomei Wu, Bo Zhu, Jinyang Yu, Bowen Yang, Jingpu Shi, The pooled incidence of post-stroke seizures in 102 008 patients, Stroke Rehabilitation, 2015, vol.22, 6

Serafini A., Gigli G., Gregoraci G., Janes F., Cancelli I., Novello S., et al. (2015) Are early seizures predictive of epilepsy after a stroke? results of a population-based study. Neuroepidemiology 45: 50-58

Silverman I., Restrepo L., Mathews G. (2002) Poststroke seizures. Arch Neurol 59: 195-201

Syvertsen M., Nakken K., Edland A., Hansen G., Hellum M., Koht J. (2015) Prevalence and etiology of epilepsy in a Norwegian county-a population based study. Epilepsia 56: 699-706.




DOI: http://dx.doi.org/10.14748/vmf.v8i1.5800

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