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Consumption and in Vitro Resistance to Gentamicin in Problematic Infections in an University Hospital

Temenuga Stoeva, Kalinka Bojkova, Milena Bojkova


The aim of this study was to investigate the dynamic of gentamicin resistance in most frequently isolated Gram negative bacteria (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii) and its correlation to the annual gentamicin consumption (DDD per 100 bed-days) during the period 2004 - 2013. The use of gentamicin was constantly increasing during the studied period, which is in correlation with the trend of increasing the rate of gentamicin resistant K. pneumoniae and A. baumannii. Increasing rates of resistance from 28% in 2004 to 39% in 2013, with peak of 48% in 2010 were detected in K. pneumoniae. During the period 2009 - 2012, а sharp rise in the development of gentamicin resistance was detected in А. baumannii: from 58% in 2009 to 78% in 2011. In E. coli, a trend of continuous increasing of gentamicin resistance was found only during the first half of the studied period (2004 - 2007), reaching the rate of 30%. In spite of the increased gentamicin consumption, stabilized rates of gentamicin resistance in E. coli (16-19%) were detected during the second half of the studied period (2008 - 2013).
A clear correlation during the studied years `increased consumption - increased resistance rate` was not found for P. aeruginosa, although the general trend for this long period of time is for increasing the gentamicin resistance in this bacterial species (from 25% to 35%).


gentamicin; antimicrobial resistance; antibiotic consumption

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