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Varna Medical Forum

Use of 18FFDG PET/CT in Patients with Acute Ischemic Stroke

Ara Kaprelyan, Pavel Bochev, Anelia Klissarova


Introduction: Brain scintigraphy is one of the basic branches of nuclear medicine, which plays an important role in the diagnosis of neurological diseases. Functional neuroimaging techniques involve both SPECT and PET. More widely application found the coregistration of SPECT/CT and SPECT/MRI that integrate functional nuclear medicine with morphological images.
Objective: To study the usefulness of (18F)-FDG PET/CT in patients with acute ischemic cerebral stroke.
Material and methods: A total of 16 cases (10 males and 6 females, aged between 39 and 80) with acute ischemic cerebral stroke, admitted to First Clinic of Neurology at UMBAL `Sveta Marina` during the period of 2008-2013 year were included in the study. (18F)-FDG PET/CT scans were obtained by means of Phillips Gemini TF machinery, following the corresponding standard protocols.
Results: In all patients were visualized hypodense and hypometabolic zones, corresponding to the location of brain infarction and border regions of reduced glucose metabolism, reflecting the so called `penumbra`.
Conclusion: Based on the literature data and our own results, we confirm the clinical application of (18F)-FDG PET/CT in patients with acute ischemic strokes. We suggest that this modern method of co-registration might be useful for assessment of structural and metabolic cerebral disorders and possesses an important diagnostic and prognostic significance for the disease outcome.


acute ischemic stroke; cerebral glucose metabolism; (18F)-FDG PET/СТ

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