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Varna Medical Forum

Key Apoptosis Signaling Pathways In Malignant Diseases

Teodorika Panayotova, Dragomir Stoyanov, Rostislav Manev, Margarita Maneva, Boryana Stefanova, Eleonora Dimitrova, Nikolay Tsonev

Abstract

Apoptosis is a process of controlled cell death in multicellular organisms. Despite complex control mechanisms, apoptosis can escape the regulatory processes, leading to cell proliferation and oncogenesis.
Several important signaling pathways affect controlled cell death, including the AKT signaling path-way and p53-mediated apoptosis pathways, as well as two major cellular pathways—external and internal, which are best studied.
The use of targeted therapies that interfere with specific molecules involved in the regulation of apoptosis is a possible new approach to cancer treatment.

Keywords

apoptosis, cancer, carcinogenesis

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DOI: http://dx.doi.org/10.14748/vmf.v10i3.8245

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