Yi X, Mroczko M, Manoj KM, Wang X, Hager LP. Replacement of the proximal heme thiolate ligand in chloroperoxidase with a histidine residue. Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12412-7. doi: 10.1073/pnas.96.22.12412. PMID: 10535936; PMCID: PMC22935.
Manoj KM, Yi X, Rai GP, Hager LP. A kinetic epoxida-tion assay for chloroperoxidase. Biochem Biophys Res Commun. 1999 Dec 20;266(2):301-3. doi: 10.1006/bbrc.1999.1810. PMID: 10600497.
Manoj KM, Lakner FJ, Hager LP. Epoxidation of indene by chloroperoxidase. Journal of Molecular Catalysis B: Enzymatic 2000 Mar 9, 107-111.DOI: 10.1016/S1381-1177(99)00118-6
Manoj KM, Hager LP. Utilization of peroxide and its relevance in oxygen insertion reactions catalyzed by chloroperoxidase. Biochim Biophys Acta. 2001 Jun 11;1547(2):408-17. doi: 10.1016/s0167-4838(01)00210-2. PMID: 11410297.
Manoj KM & Hager LP The catalytic utility and versatility of chloroperoxidase. Invited book chapter in Recent Research Developments in Organic Chemistry 2002:6, 393. Transworld Research Network. ISBN:81-7895-041-3.
Wang X, Tachikawa H, Yi X, Manoj KM, Hager LP. Two-dimensional NMR study of the heme active site structure of chloroperoxidase. J Biol Chem. 2003 Mar 7;278(10):7765-74. doi: 10.1074/jbc.M209462200. Epub 2002 Dec 16. PMID: 12488315.
Manoj KM, Hager LP. A colorimetric method for de-tection and quantification of chlorinating activity of hemeperoxidases. Anal Biochem. 2006 Jan 1;348(1):84-doi: 10.1016/j.ab.2005.10.014. Epub 2005 Oct 26. PMID: 16289436.
Manoj KM. Chlorinations catalyzed by chloroperoxidase occur via diffusible intermediate (s) and the reaction components play multiple roles in the overall process. Biochimica et Biophysica Acta (BBA)-Proteins & Proteomics 2006 Aug, 1764, 1325-1339. DOI: 10.1016/j. bbapap.2006.05.012
Manoj KM Hager LP. Chloroperoxidase, a janus enzyme. Biochemistry 2008 Mar, 47, 2997-3003. DOI: 10.1021/bi7022656
Manoj KM, Baburaj A, Ephraim B, Pappachan F, Maviliparambathu PP, Vijayan UK, Narayanan SV, Periasamy K, George EA, Mathew LT. Explaining the atypical reaction profiles of heme enzymes with a novel mechanistic hypothesis and kinetic treatment. PLoS One. 2010 May 17;5(5):e10601. doi: 10.1371/journal.pone.0010601. PMID: 20498847; PMCID: PMC2871781.
Manoj KM, Gade SK, Mathew L. Cytochrome P450 reductase: a harbinger of diffusible reduced oxygen species. PLoS One. 2010 Oct 13;5(10):e13272. doi: 10.1371/journal. pone.0013272. PMID: 20967245; PMCID: PMC2954143.
Andrew D, Hager L, Manoj KM. The intriguing enhancement of chloroperoxidase mediated one-electron oxidations by azide, a known active-site ligand. Biochem Biophys Res Commun. 2011 Dec 2;415(4):646-9. doi: 10.1016/j.bbrc.2011.10.128. Epub 2011 Nov 3. PMID: 22079633.
Parashar A, Manoj KM. Traces of certain drug molecules can enhance hemeenzyme catalytic outcomes. Biochem Biophys Res Commun. 2012 Jan 20;417(3):1041-5. doi: 10.1016/j.bbrc.2011.12.090. Epub 2011 Dec 26. PMID: 22214932.
Gideon DA, Kumari R, Lynn AM, Manoj KM. What is the Functional Role of N-terminal Transmembrane Helices in the Metabolism Mediated by Liver Microsomal Cytochrome P450 and its Reductase? Cell Biochem Biophys. 2012 Feb 1. doi: 10.1007/s12013-012-9339-0. Epub ahead of print. PMID: 22302675.
Gade SK, Bhattacharya S, Manoj KM. Redox active molecules cytochrome c and vitamin C enhance heme-enzyme peroxidations by serving as non-specific agents for redox relay. Biochem Biophys Res Commun. 2012 Mar 9;419(2):211-4. doi: 10.1016/j.bbrc.2012.01.149. Epub 2012 Feb 9. PMID: 22342667.
Parashar A, Gade SK, Potnuru M, Madhavan N, Manoj KM. The curious case of benzbromarone: insight into super-inhibition of cytochrome P450. PLoS One. 2014 Mar 3;9(3):e89967. doi: 10.1371/journal.pone.0089967. PMID: 24594849; PMCID: PMC3940698.
Parashar A, Venkatachalam A, Gideon DA, Manoj KM. Cyanide does more to inhibit heme enzymes, than merely serving as an active-site ligand. Biochem Bio-phys Res Commun. 2014 Dec 12;455(3-4):190-3. doi: 10.1016/j.bbrc.2014.10.137. Epub 2014 Nov 6. PMID: 25449264.
Manoj KM, Venkatachalam A, Parashar P. Metabolism of xenobiotics by cytochrome P450: novel insights into the thermodynamics, kinetics and roles of redox proteins and diffusible reactive species. Drug Me-tabolism Reviews 2016 Jan, 48, 41-42, 2016/1/1. DOI: 10.1080/03602532.2016.1191843
Manoj KM, Gade SK, Venkatachalam A, and Gideon DA. Electron transfer amongst fl€avo- and hemo-proteins: diffusible species effect the relay processes, not protein-protein binding. RSC Advances 2016. 6: 24121-24129.
Venkatachalam A, Parashar A, Manoj KM. Functioning of drug-metabolizing microsomal cytochrome P450s: In silico probing of proteins suggests that the distal heme `active site` pocket plays a relatively `passive role` in some enzyme-substrate interactions. In Silico Pharmacol. 2016 Dec;4(1):2. doi: 10.1186/s40203-016-0016-7. Epub 2016 Feb 19. PMID: 26894412; PMCID: PMC4760962
Manoj KM, Parashar A, Venkatachalam A, Goyal S, Satyalipsu, Singh PG, Gade SK, Periyasami K, Jacob RS, Sardar D, Singh S, Kumar R, Gideon DA. Atypical profiles and modulations of heme-enzymes catalyzed outcomes by low amounts of diverse additives sug-gest diffusible radicals` obligatory involvement in such redox reactions. Biochimie. 2016 Jun;125:91-111. doi: 10.1016/j.biochi.2016.03.003. Epub 2016 Mar 10. PMID: 26969799.
Manoj KM, Parashar A, Gade SK, Venkatachalam A. Functioning of Microsomal Cytochrome P450s: Murburn Concept Explains the Metabolism of Xenobiotics in Hepatocytes. Front Pharmacol. 2016 Jun 23;7:161. doi: 10.3389/fphar.2016.00161. PMID: 27445805; PMCID: PMC4918403.
Manoj KM. Debunking chemiosmosis and proposing murburn concept as the operative principle for cellular respiration. Biomedical Reviews 2017, 28, 31-48. DOI: 10.14748/bmr.v28.4450
Parashar A, Gideon DA, Manoj KM. Murburn Concept: A Molecular Explanation for Hormet-ic and Idiosyncratic Dose Responses. Dose Re-sponse. 2018 May 9;16(2):1559325818774421. doi: 10.1177/1559325818774421. PMID: 29770107; PMCID: PMC5946624.
Manoj KM. Aerobic Respiration: Criticism of the Proton-centric Explanation Involving Rotary Adeno-sine Triphosphate Synthesis, Chemiosmosis Principle, Proton Pumps and Electron Transport Chain. Biochem Insights. 2018 Dec 25;11:1178626418818442. doi: 10.1177/1178626418818442. PMID: 30643418; PMCID: PMC6311555.
Manoj KM. The ubiquitous biochemical logic of murburn concept. Biomedical Reviews (2018). 29: 89-97. DOI: 10.14748/bmr.v29.5854
Manoj KM, Gideon DA, and Jacob VD. Murburn scheme for mitochondrial thermogenesis. Biomedical Reviews 2018. 29: 73-82. DOI: 10.14748/bmr.v29.5852
Gideon DA, Jacob VD, Manoj KM. 2020: murburn concept heralds a new era in cellular bioenergetics. Bio-medical Reviews 2019, 30, 89-98. DOI: 10.14748/bmr. v30.6390
Manoj KM. Torday`s prognosis for aging and mortality: more evolution and better life! Biomedical Reviews 2019, 30, 23-24. DOI: 10.14748/bmr.v30.6384
Jacob VD, Manoj KM. Are adipocytes and ROS vil-lains, or are they protagonists in the drama of life? The murburn perspective. Adipobiology 2019, 10, 7-16. DOI: 10.14748/adipo.v10.6534
Manoj KM, Parashar A, David Jacob V, Ra-masamy S. Aerobic respiration: proof of concept for the oxygen-centric murburn perspective. J Bio-mol Struct Dyn. 2019 Oct;37(17):4542-4556. doi: 10.1080/07391102.2018.1552896. Epub 2019 Jan 8. PMID: 30488771.
Manoj KM, Soman V, David Jacob V, Parashar A, Gideon DA, Kumar M, Manekkathodi A, Ramasamy S, Pakshirajan K, Bazhin NM. Chemiosmotic and murburn explanations for aerobic respiration: Predictive capabili-ties, structure-function correlations and chemico-physical logic. Arch Biochem Biophys. 2019 Nov 15;676:108128. doi: 10.1016/j.abb.2019.108128. Epub 2019 Oct 14. PMID: 31622585.
Manoj KM. Refutation of the cation-centric torsional ATP synthesis model and advocating murburn scheme for mitochondrial oxidative phosphorylation. Biophys Chem. 2020a Feb;257:106278. doi: 10.1016/j.bpc.2019.106278. Epub 2019 Nov 18. PMID: 31767207.
Manoj KM. Murburn concept: a paradigm shift in cellular metabolism and physiology. Biomol Concepts. 2020b Jan 22;11(1):7-22. doi: 10.1515/bmc-2020-0002. PMID: 31961793.
Manoj KM, Soman V. Classical and murburn explanations for acute toxicity of cyanide in aerobic respiration: A per-sonal perspective. Toxicology. 2020 Feb 28;432:152369. doi: 10.1016/j.tox.2020.152369. Epub 2020 Jan 30. PMID: 32007488.
Manoj KM, Ramasamy S, Parashar A, Gideon DA, So-man V, Jacob VD, Pakshirajan K. Acute toxicity of cya-nide in aerobic respiration: Theoretical and experimental support for murburn explanation. Biomol Concepts. 2020 Mar 17;11(1):32-56. doi: 10.1515/bmc-2020-0004. PMID: 32187011.
Manoj KM, Jacob VD. Murburn precepts for photorecep-tion. Biomdical Reviews 2020, 31:67-74. DOI: 10.14748/bmr.v31.7706
Manoj KM. In defense of the murburn explanation for aerobic respiration. Biomedical Reviews 2020, 31:135-160. DOI: 10.14748/bmr.v31.7713. Also refer the Supplementary Information in the issue. DOI: 10.14748/bmr.v31.7714
Manoj KM and Manekkathodi A. Light`s interaction with pigments in chloroplasts: The murburn perspective. Journal of Photochemistry and Photobiology 2021, 5: 100015. DOI: 10.1080/07391102.2020.1835715
Manoj KM, Gideon DA, Parashar A. What is the Role of Lipid Membrane-embedded Quinones in Mitochondria and Chloroplasts? Chemiosmotic Q-cycle versus Mur-burn Reaction Perspective. Cell Biochem Biophys. 2021 Mar;79(1):3-10. doi: 10.1007/s12013-020-00945-y. Epub 2020 Sep 29. PMID: 32989571.
Gideon DA, Nirusimhan V, Manoj KM. Are plas-tocyanin and ferredoxin specific electron carriers or generic redox capacitors? Classical and mur-burn perspectives on two photosynthetic proteins. J Biomol Struct Dyn. 2022 Mar;40(5):1995-2009. doi: 10.1080/07391102.2020.1835715. Epub 2020 Oct 19. PMID: 33073701.
Parashar A, Manoj KM. Murburn Precepts for Cy-tochrome P450 Mediated Drug/Xenobiotic Metabolism and Homeostasis. Curr Drug Metab. 2021;22(4):315-326. doi: 10.2174/1389200222666210118102230. PMID: 33461459.
Parashar A, Jacob VD, Gideon DA, Manoj KM. Hemo-globin catalyzes ATP-synthesis in human erythrocytes: a murburn model. J Biomol Struct Dyn. 2021 May 17:1-13. doi: 10.1080/07391102.2021.1925592. Epub ahead of print. PMID: 33998971.
Gideon DA, Nirusimhan V, E JC, Sudarsha K, Manoj KM. Mechanism of electron transfers medi-ated by cytochromes c and b5 in mitochondria and endoplasmic reticulum: classical and murburn perspec-tives. J Biomol Struct Dyn. 2021 May 17:1-18. doi: 10.1080/07391102.2021.1925154. Epub ahead of print. PMID: 33998974.
Manoj KM, Bazhin NM. The murburn precepts for aero-bic respiration and redox homeostasis. Prog Biophys Mol Biol. 2021 Dec;167:104-120. doi: 10.1016/j.pbiomol-bio.2021.05.010. Epub 2021 Jun 10. PMID: 34118265.
Manoj KM, Bazhin NM, Jacob VD, Parashar A, Gideon DA, Manekkathodi A. Structure-function correlations and system dynamics in oxygenic photosynthesis: classical perspectives and murburn precepts. J Biomol Struct Dyn. 2021 Jul 29:1-27. doi: 10.1080/07391102.2021.1953606. Epub ahead of print. PMID: 34323659.
Manoj KM, Gideon DA, Parashar A, Nirusimhan V, An-nadurai P, Jacob VD, Manekkathodi A. Validating the predictions of murburn model for oxygenic photosyn-thesis: Analyses of ligand-binding to protein complexes and cross-system comparisons. J Biomol Struct Dyn. 2021 Jul 30:1-33. doi: 10.1080/07391102.2021.1953607. Epub ahead of print. PMID: 34328391.
Manoj KM, Bazhin N, Tamagawa H. The murburn precepts for cellular ionic homeostasis and electrophysi-ology. J Cell Physiol. 2022 Jan;237(1):804-814. doi: 10.1002/jcp.30547. Epub 2021 Aug 11. PMID: 34378795.
Manoj KM, Bazhin N, Wu Y, Manekkathodi A. Mur-burn model of photosynthesis: Effect of additives like chloride and bicarbonate. In Chlorophylls (2022). ISBN 978-1-80355-487-7. Edited by Ameen S. et al., Intech Open. DOI: 10.5772/intechopen.103132.
Manoj KM, Tamagawa H. Critical analysis of expla-nations for cellular homeostasis and electrophysiol-ogy from murburn perspective. J Cell Physiol. 2022 Jan;237(1):421-435. doi: 10.1002/jcp.30578. Epub 2021 Sep 13. PMID: 34515340.
Manoj KM, Gideon DA, Jaeken L. Why do cells need oxygen? Insights from mitochondrial composition and function. Cell Biol Int. 2022 Mar;46(3):344-358. doi: 10.1002/cbin.11746. Epub 2021 Dec 28. PMID: 34918410.
Gideon DA, Parashar A, Robin J, Annadurai P, Nirusim-han V, Manoj KM. Do cyclooxygenases possess a mur-zyme activity? Biomedical Reviews 2021. 32:47-59. DOI: 10.14748/bmr.v32.8503
Manoj KM, Nirusimhan V, Parashar A, Edward J, Gideon DA. Murburn precepts for lactic-acidosis, Cori cycle, and Warburg effect: Interactive dynamics of de-hydrogenases, protons, and oxygen. J Cell Physiol. 2022 Mar;237(3):1902-1922. doi: 10.1002/jcp.30661. Epub 2021 Dec 20. PMID: 34927737.
Manoj KM, Gideon DA, Jaeken L. Interaction of mem-brane-embedded cytochrome b-complexes with quinols: Classical Q-cycle and murburn model. Cell Biochem Funct. 2022 Mar;40(2):118-126. doi: 10.1002/cbf.3682. Epub 2022 Jan 13. PMID: 35026863.
Manoj KM, Bazhin NM, Tamagawa H, Jaeken L, Parashar A. The physiological role of complex V in ATP synthesis: Murzyme functioning is viable whereas rotary conforma-tion change model is untenable. J Biomol Struct Dyn. 2022 Apr 8:1-20. doi: 10.1080/07391102.2022.2060307. Epub ahead of print. PMID: 35394896.
Manoj KM, Tamagawa H, Bazhin N, Jaeken L, Nirusim-han V, Faraci F, Gideon DA. Murburn model of vision: Precepts and proof of concept. J Cell Physiol. 2022 Aug;237(8):3338-3355. doi: 10.1002/jcp.30786. Epub 2022 Jun 6. PMID: 35662017.
Manoj KM, Gideon DA. Structural foundations for explaining the physiological roles of murzymes em-bedded in diverse phospholipid membranes. Biochim Biophys Acta Biomembr. 2022 Oct 1;1864(10):183981. doi: 10.1016/j.bbamem.2022.183981. Epub 2022 Jun 8. PMID: 35690100.
Manoj KM, Gideon DA, Bazhin NM, Tamagawa H, Nirusimhan V, Kavdia M, Jaeken L. Na, K-ATPase: A murzyme facilitating thermodynamic equilibriums at the membrane-interface. Journal of Cellular Physiology 2022. DOI: 10.1002/jcp.30925
Manoj KM. Murburn concept and murzymes in 2023: Celebrating 25th year of pursuit. Biomedical Reviews 2022, 33, 1.
Manoj KM. Iconoclasm and innovation: The inevitable and the appreciable facets of murburn concept. Biomedi-cal Reviews 2022, 33, 49
Manoj KM, Manekkathodi A, Bazhin N, Parashar A, Wu Y. Comprehensive analyses of enhancement of ox-ygenesis in photosynthesis by bicarbonate and effects of diverse additives: Z-scheme versus murburn model. In Plant Physiology Annual Volume 2023, edited by Jen-Tsung Chen & Tomasz Brzozowski. Intech Open. doi: 10.5772/intechopen.106996.
Manoj KM. Murburn post-translational modifications of proteins: Cellular redox processes and murzyme-mediat-ed metabolo-proteomics. Journal of Cellular Physiology 2022, 239, e30954.
Manoj KM, et al. Questioning physiological rotary functionality in bacterial fl€agellar system and propos-ing a murburn model for motility. Journal of Biomo-lecular Structure and Dynamics 2023, 41, 15691. doi: 10.1080/07391102.2023.2191146
Manoj KM, Jaeken L Synthesis of theories on cellular powering, coherence, homeostasis and electro-mechan-ics: Murburn concept & evolutionary perspectives. Jour-nal of Cellular Physiology 2023, 238, 931. doi: 10.1002/jcp.31000
Manoj KM. What is the relevance of murburn concept in thalassemia and respiratory diseases? Thalassemia Reports 2023, 13, 144.
Manoj KM. The murburn rationale for phosphatidyletha-nolamine’s modulation of UCP1 mediated thermogenesis. Science Advances (eLetter) 2023. doi: 10.1126/sciadv. ade7864
Manoj KM. Murburn concept provides a thermodynami-cally valid and kinetically facile oxygen-centric explana-tion for mitochondrial heat generation. Science (eLetter) 2023. doi: 10.1126/science.abl7108
Manoj KM, et al. Murburn concept in cellular function and bioenergetics, Part 1: Understanding murzymes at the molecular level. AIP Advances 2023, 13, 120702.
Manoj KM, et al. Murburn concept in cellular function and bioenergetics, Part 2: Understanding integrations-translations from molecular to macroscopic levels. AIP Advances 2023, 13, 120701.
Manoj KM. Shunning of murburn concept: A sham and a shame! Biomedical Reviews 2023, 34, 165.
Manoj KM. Murburn concept: Murzyme roles of redox proteins in xenobiotic metabolism and ATP-synthesis. Biomedical Reviews 2023, 34, 27.
Manoj KM, Manekkathodi A. Murburn concept, a sto-chastic principle for evolution and synthesis of cellular functions. OSF Preprints 2023 (https://doi.org/10.31219/osf.io/ycr5g) [Proceedings of the 30th Swadeshi Science Congress, 69-82.]
KM Manoj. Why is oxygen needed for life? Discredit-ing prevailing ideas, murburn concept affords viable explanations. Sasthra, The Indian Journal of Science and Technology 4 (6): 33-40.
Manoj, K. M., & Gideon, D. A. The abundance of lysine-arginine residues in loops and channel of UCP1 supports the oxygen-centric murburn model for thermogenesis, anion-transport and uncoupling. OSF Preprints 2023. htt-ps://doi.org/10.31219/osf.io/5rpq8 [Originally published in Science Advances 2023 as an eLetter at https://www. science.org/doi/10.1126/sciadv.adh4251 and unilaterally retracted by the publisher sans any rebuttal or advisory, after two months.]
Manoj, K. M. The murburn explanation for redox-phos-phorylative coupling by Complex I. OSF Preprints 2023. https://doi.org/10.31219/osf.io/5vkc7. [eLetter submitted against the arguments/inferences advocated in the Sci-ence 2020 article: https://www.science.org/doi/10.1126/science.abc4209]
Manoj, K. M. The murzyme role of respiratory Complex I and understanding its modulation. OSF Preprints 2023. https://doi.org/10.31219/osf.io/grc5t. [eLetter submitted against the arguments/inferences advocated in the Sci-ence 2023 article: https://www.science.org/doi/10.1126/science.ade3332]
Manoj, K. M. Murburn electron-transfers versus the con-cept of `electron transport chain’: Probability versus de-terminism. OSF Preprints 2023. https://doi.org/10.31219/osf.io/xuwts. [eLetter submitted against the arguments/inferences advocated in the Science 2021 article: https://www.science.org/doi/10.1126/science.abi7495]
Manoj, K. M. Complex V is an ATPase-based proton-chemostat, not a rotary ATP-synthase. OSF Preprints 2023. https://doi.org/10.31219/osf.io/4c2ud. [eLetter submitted against the arguments/inferences advocated in the Science 2019 article: https://www.science.org/doi/10.1126/science.aaw9128]
Manoj, K. M. Reinterpreting the working mechanism of Complex I with murburn concept. OSF Preprints 2023. https://doi.org/10.31219/osf.io/qv2ud. [eLetter submitted against the arguments/inferences advocated in the Sci-ence Advances 2023 article: https://www.science.org/doi/10.1126/sciadv.adi1359]
Manoj, K. M., & Jacob, V. D. Murburn model of vision supports multi-layered photoreception and signal relay networks in human eye. OSF Preprints 2024. https://doi.org/10.31219/osf.io/dc5m3. [Communicated as a Letter to the Editor in response to the findings reported in Neuron 2023 article: doi: 10.1016/j.neuron.2023.06]
Manoj, K. M. Diffusible reactive (oxygen) species CAN-NOT be disconnected from cellular functioning or bioen-ergetics. OSF Preprints 2024. https://doi.org/10.31219/osf.io/a2yp9. [Communicated as a Letter to the Editor in response to the findings reported in PNAS 2024 article: https://doi.org/10.1073/pnas.23079041]
Jaeken, L., & Manoj, K. M. Murburn redox bioenerget-ics and ROS-radiations connectivity: Insights into the origin, evolution, sustenance and termination of life! OSF Preprints 2024. https://doi.org/10.31219/osf.io/ms83n
Manoj, K. M., Venugopal, V., & Sabapathy, S. Seam-less chemo-electrical and radiative interfacing of `living organic systems’ with `man-made electro-mechanical components’ via murburn concept. OSF Preprints 2024 https://doi.org/10.31219/osf.io/68ryp
Gideon, D. A., Annadurai, P., Parashar, A., & Manoj, K. M. Re-interpretation of structure-function correlations and inhibitions of mammalian cyclooxygenase isozymes with murburn concept. OSF Preprints 2024, https://doi. org/10.31219/osf.io/t9wrn [The latest version is published in the current edition of Biomedical Reviews.]
Manoj, K. M., Gideon, D. A., & Soman, V. Consolida-tion of the murburn model of fl€agella-aided motility in bacteria. OSF Preprints 2024. https://doi.org/10.31219/osf.io/egdps [The latest version is published in the current edition of Biomedical Reviews.]
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