Life-sustaining mechanisms were primarily understood within the purview of: (i) intelligent cellular/organellar membranes guarding/maintaining their internal milieu deterministically, and (ii) the cellular activities being governed by directional information-flow via the central dogma. In this schema, cellular coherence (inter-molecular networking to achieve functional unitization) and homeostasis/electrophysiology were explained by the concentration-dependent interaction unidirectional positively correlated dynamics of catalytic enzymes-substrates, electron donors-acceptors, signalling receptors-ligands, channels-ions, antibodies-antigens, etc. Such treatments entailed selective/specific and topology-based (affinity-driven) stoichiometric interactions. Also, only the impact of external radiations (like X-rays, UV-Vis-IR light, micro/radio waves, etc.) on living systems have found prominence in biomedical literature, with lesser information on internally generated or readdressed low/high-frequency radiations. The above long-standing paradigm has witnessed a major upheaval in the last decade with the unravelling of murburn concept, which postulates that diffusible reactive species (DRS) and murzymes (proteins that recruit DRS in routine functions) are a fundamental pivot of life that aid catalytic moiety-/electron-transfers, phase-changes, post-translational modifications, etc. within the cells, thereby serving diverse agenda of its function. The murburn theorization solicits cellular “Chemico-Electromagnetic Matrix (CEM) with “molecule-unbound ion-radical/radiation interactions”, which provides powering and coherence for living systems, and explains why oxygen became the elixir of life. Herein, we project tangible framework/examples of how murburn concept could afford a seamless interlacing of man-made synthetic components with biological systems, particularly within the contexts of intelligence/controls, bioenergetics, metabolic and sensing-response agenda. We also discuss mandates wherein analog-digital conversions could be achieved, and project the scope and limitations of murburn-based approach in futuristic bionic-cyborg technology. Biomed Rev 2025; 36: 31-43
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