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Biomedical Reviews

Mechanisms underlying the development of gastroesophageal reflux disease

Dobromir Dobrev, Boris Kornovski, Bogomila Manevska


In recent years, a large deal of new information accumulated concerning the pathogenesis, diagnosis, and therapy of gastroesophageal reflux disease (GERD). Gastric contents, mucosal resistance and clearing, and gastric emptying, along with incompetence of the lower esophageal sphincter, are now recognized as contributing factors to the development of GERD. In this review, the discussion is concentrated on the diagnostic tests for detecting GERD and their accuracy as well as on the potential mechanisms underlying the development of GERD.

Biomedical Reviews 1997; 8: 101-109.

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About The Authors

Dobromir Dobrev
Medical University of Varna

Boris Kornovski
Medical University of Varna

Bogomila Manevska
Medical University of Varna

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