In recent years, a large deal of new information accumulated concerning the pathogenesis, diagnosis, and therapy of gastroesophageal reflux disease (GERD). Gastric contents, mucosal resistance and clearing, and gastric emptying, along with incompetence of the lower esophageal sphincter, are now recognized as contributing factors to the development of GERD. In this review, the discussion is concentrated on the diagnostic tests for detecting GERD and their accuracy as well as on the potential mechanisms underlying the development of GERD.
Biomedical Reviews 1997; 8: 101-109.
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