The sympathetic nervous system has been considered to be hyperactive from the very beginning after birth in spontaneously hypertensive and stroke-prone spontaneously hypertensive rats. This is a primary factor for the development and maintenance of hypertension via structural and functional alterations of the arteries and the heart. It is also described that the sympathetic hyperfunction probably play a protective role in necrosis of vascular smooth muscle cells in spontaneously hypertensive and stroke-prone spontaneously hypertensive rats.
Biomedical Reviews 1996; 6: 57-68.
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