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Biomedical Reviews

Dual effect of sympathetic hyperfunction on blood vessels in spontaneously hypertensive and stroke-prone spontaneously hypertensive rats

Mari Kondo, Tatyana Tenkova, Takashi Fujiwara

Abstract

The sympathetic nervous system has been considered to be hyperactive from the very beginning after birth in spontaneously hypertensive and stroke-prone spontaneously hypertensive rats. This is a primary factor for the development and maintenance of hypertension via structural and functional alterations of the arteries and the heart. It is also described that the sympathetic hyperfunction probably play a protective role in necrosis of vascular smooth muscle cells in spontaneously hypertensive and stroke-prone spontaneously hypertensive rats.

Biomedical Reviews 1996; 6: 57-68.


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DOI: http://dx.doi.org/10.14748/bmr.v6.172

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About The Authors

Mari Kondo
Ehime University School of Medicine
Japan

Tatyana Tenkova
Washington University in St. Louis
United States

Takashi Fujiwara
Ehime University School of Medicine
Japan

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