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Biomedical Reviews

A novel virus removal filter and its application

Sei-Ichi Manabe, Naoki Yamamoto


The novel virus removal membrane BMM and the commercially available filter PLANOVAâ„¢ based on this system provide results both reproducible and predictable for virus removal based on a sieving mechanism. The BMM shows good removability of most viruses, including human immunodeficiency virus, hepatitis B and C and other microorganisms. In addition, immune complexes can be removed efficiently with a good protein permeability. Although BMM has already been shown to be effective in the field of drug manufacture, the combination of virus removal using BMM with virus inactivation offers opportunities for the wider clinical application of BMM, including blood transfusion.

Biomedical Reviews 1996; 6: 95-109.

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About The Authors

Sei-Ichi Manabe
Fukuoka Women s University

Naoki Yamamoto
Tokyo Medical and Dental University School of Medicine

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