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Biomedical Reviews

Neural-immune-effector (NIE) cross-talk in vascular trophobiology: proposal for new and not yet exploited purinergic regulatory mechanisms

George N. Chaldakov, Peter I. Ghenev, Matei Andonov, Kamen P. Valchanov, Anton B. Tonchev, Rouzha Pancheva

Abstract

In a state-of-the-art approach, Dr. Hasséssian presents purinoceptor-mediated vasoconstriction/vasodilation mechanisms of the pulmonary circulation. He focuses on P2 purinoceptors of smooth muscle cells, endothelial cells, platelets and mast cells, without addressing P1 (adenosine) purinoceptors. Recently, the Burnstock's purinoceptorology is "arborizing" into a variety of members of P1 and P2 purinoceptor families classified by the International Union of Pharmacology. Here we would like to add some possible, new and not yet exploited, purinergic regulatory mechanisms to the Hasséssian's work. Accordingly, we shall briefly focus on the involvement of connective tissue (adventitial) mast cells and their interactions with perivascular nerves and medial smooth muscle cells.

Biomedical Reviews 1994; 3: 81-86.


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DOI: http://dx.doi.org/10.14748/bmr.v3.205

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About The Authors

George N. Chaldakov
Medical University of Varna
Bulgaria

Peter I. Ghenev
Medical University of Varna
Bulgaria

Matei Andonov
Medical University of Varna
Bulgaria

Kamen P. Valchanov
Medical University of Varna
Bulgaria

Anton B. Tonchev
Medical University of Varna
Bulgaria

Rouzha Pancheva
Medical University of Varna
Bulgaria

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