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From Antitubulins to Trackins

Stanislav Yanev, Marco Fiore, Alexander Hinev, Peter Ghenev, Mariyana Hristova, Plamen Panayotov, Anton Tonchev, Nikolay Evtimov, Luigi Aloe, George N Chaldakov

Abstract

Microtubules (MT) are dynamically instable, assembling and disassembling structures of the cell. Tubulin, the major building protein of MT, is a heterodimer consisting of α and ẞ subunits. Agents that bind to tubulin and inhibit its assembly lead to the inhibition of MT formation. Such tubulin-binding agents are usually termed MT-disassembling agents or antitubulins. Endocytosis, matrix protein secretion, cell division, cell migration and inflammation are examples of MT-dependent processes. Their dysfunction, in particular in arterial smooth muscle cells (ASMC), is critically involved in atherogenesis. Here we Dance round (i) MT-based secretory pathway in ASMC and, in turn, antitubulins for atherosclerosis therapy, and (ii) the neurotrophins, particularly nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) and their receptors Trk (tyrosine receptor kinase; pronounced `track`), introducing the term trackins - Trk-targeting agents (TTA) that influence positively (agonistically) or negatively (antagonistically) the activity of TrkA receptor for NGF and/or TrkB receptor for BDNF. We propose that some trackins and their native ligands may have therapeutic potentials for cardiometabolic, neuropsychiatric, oncologic and other diseases. Finally the interaction of MT-tubulin and neurotrophin Trk receptors is outlined.


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DOI: http://dx.doi.org/10.14748/bmr.v27.2112

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About The Authors

Stanislav Yanev
Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria
Bulgaria

Department of Drug Toxicology

Marco Fiore
National Research Council (CNR), Rome, Italy
Italy

Institute of Cell Biology and Neurobiology

Alexander Hinev
University St Marina Hospital, Varna, Bulgaria
Bulgaria

Department of Urology

Peter Ghenev
Medical University, Varna, Bulgaria
Bulgaria

Department of Pathology

Mariyana Hristova
Asparuhovo Polyclinic, Varna, Bulgaria
Bulgaria

Endocrinology Unit

Plamen Panayotov
University St Marina Hospital, Varna, Bulgaria
Bulgaria

Department of Cardiac Surgery

Anton Tonchev
Medical University, Varna, Bulgaria
Bulgaria

Department of Anatomy and Histology

Nikolay Evtimov
Urology Clinic, St Anna Hospital, Varna, Bulgaria
Bulgaria

Luigi Aloe
Institute of Cell Biology and Neurobiology, National Research Council (CNR), Rome, Italy
Italy

George N Chaldakov
Medical University, Varna, Bulgaria
Bulgaria

Laboratory of Cell Biology, Department of Anatomy and Histology

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