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Biomedical Reviews

Thyroid hormones paradox, oxidative stress, and selenium

Adela Elena Joanta, Sanda Andrei, Nicoleta Decea, Remus Moldovan, Adriana Muresan

Abstract

Reactive oxygen species (ROS) play an important role in physiological processes, but - when being in excess - ROS cause oxidative damage to molecules. Under physiological conditions, the production and detoxification of ROS are more-or-less balanced. Also in the thyroid, ROS and free radicals participate in physiological and pathological processes in the gland. For example, hydrogen peroxide (H2O2) is crucial for thyroid hormone biosynthesis, acting at different steps of the process. Additionally, H2O2 is believed to participate in the Wolff-Chaikoff`s effect, undergoing in conditions of iodide excess in the thyroid. It is the purpose of this review to attempt a synthesis of what we currently know of thyroid hormones production and their relation to oxidative stress and selenium, a trace element.

Biomedical Reviews 2009; 20: 17-29.


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DOI: http://dx.doi.org/10.14748/bmr.v20.51

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About The Authors

Adela Elena Joanta
Iuliu Hațieganu University of Medicine and Pharmacy of Cluj-Napoca
Romania

Sanda Andrei
University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca
Romania

Nicoleta Decea
Iuliu Hațieganu University of Medicine and Pharmacy of Cluj-Napoca
Romania

Remus Moldovan
Iuliu Hațieganu University of Medicine and Pharmacy of Cluj-Napoca
Romania

Adriana Muresan
Iuliu Hațieganu University of Medicine and Pharmacy of Cluj-Napoca
Romania

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