Johansson SG, Hourihane JO, Bousquet J, Bruijnzeel-Koomen C, Dreborg S, Haahtela T, et al. EAACI (the European Academy of Allergology and Cinical Immunology) nomenclature task force. A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy 2001; 56: 813–824. DOI:10.1034/j.1398-9995.2001.t01-1-00001.x
Pawankar R. Allergic diseases and asthma: A global public health concern and a call to action. World Allergy Organ J 2014; 7: 12. DOI: 10.1186 / 1939-4551-7-12
Soriano JB, Abajobir AA, Abate KH, Abera SF, Agrawal A, Ahmed MB, et al. Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pul-monary disease and asthma, 1990-2015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet Respir Med 2017; 5: 691–706. DOI: 10.1016 /S2213-2600 (17) 30293-X
Fedortsiv O, Brozek GM, Luchyshyn N, Kubey I, Lawson JA, Rennie DC, et al. Prevalence of childhood asthma, rhinitis, and eczema in the Ternopil region of Ukraine - Results of BUPAS study (2012). Adv Med Sci 2012; 57 (2): 282-289. https://doi.org/10.2478/v10039-012-0034-6
Guilbert TW, Garris C, Jhingran P, Bonafede M, Tomasze-wski KJ, Bonus T, et al. Asthma that is not well-controlled is associated with increased healthcare utilization and decreased quality of life. J Asthma 2011; 48: 126-132. DOI:10.3109 / 02770903.2010.535879
Wu L.S.-S, Sjakste T, Sakalauskas R, Sitkauskiene B, Paramonova N, Gasiuniene E, et al. The burden of allergic asthma in children: a landscape comparison based on data from Lithuanian, Latvian, and Taiwanese populations. Pediatr Neonatol 2012; 53: 276-282. https://doi. org/10.1016/j.pedneo.2012.08.001
Shurin MR, Smolkin YS. Immune-mediated diseases: where do we stand? Adv Exp Med Biol 2007; 601:3-12.
Masoli M, Fabian D, Holt S, Beasley R. The global burden of asthma. Available from: http://www.gi-nasthma.org/local/uploads/files/ GINABurdenReport_1. pdf. Accessed July 17, 2015. DOI: 10.1111 / j.1398-9995.2004.00526.x
International Study of Asthma and Allergies in Child-hood. The Global Asthma Report 2011. Paris: Interna-tional Union Against Tuberculosis and Lung Disease; 2011. Available from: http://isaac.auckland.ac.nz/resources/Global Asthma Report 2011.pdf. Accessed: January 11, 2016.
Soriano JB, Campos HS. Epidemiology of asthma. 2012. Available from: http://www.sopterj.com.br/profissionais/_revista/2012/n_02/03. pdf. Accessed: January 11, 2016. doi: 10.2147/TCRM.S98100
Hong S, Son DK, Lim WR. The prevalence of atopic dermatitis, asthma, and allergic rhinitis and the comorbidity of allergic diseases in children. Environ Health Toxicol. 2012;27:e2012006. doi: 10.5620/eht.2012.27.e2012006
Patelarou E, Giourgouli G, Lykeridou A, Vrioni E, Fotos N, Siamaga E, et al. Association between biomarker-quantified antioxidant status during pregnancy and infancy and allergic disease during early childhood: a systematic review. Nutr Rev 2011; 69:627-41. https://doi.org/10.1111/j.1753-4887.2011.00445.x
Bock M, Schmidt A, Bruckner T, Diepgen TL. Occupational skin disease in the construction industry, Br J Dermatol 2003; 149:1165–1171. DOI: 10.1111/j.1365-2133.2003.05748.x
Ricketts JR, Rothe MJ, Grant-Kels JM. Nutrition and psoriasis. Clin Dermatol 2010; 28:615–626.
Gupta KB, Verma M. Nutrition and asthma. Lung India 2007; 24:105–114.
Roel E, Faresjo O, Zetterstrom O, Faresjo T. Perinatal, social, and environmental factors and the risk for childhood asthma in a 10-year follow-up. Pediatr Asthma Allergy Immunol 2004; 17 (2):136-145. https://doi. org/10.1089/0883187041269931
Brehm JM, Celedo´n JC, Soto-Quiros ME. Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am J Respir Crit Care Med 2009; 179(9):765–771. https://dx.doi.org/10.1016%2Fj. jaci.2010.03.043
Feary J, Britton J. Dietary supplements and asthma: another one bites the dust. Thorax 2007; 62(6):466–468. https://doi.org/10.1136/thx.2006.073866
Rubin RN, Navon L, Cassano PA. Relationship of serum antioxidants to asthma prevalence in youth. Am J Respir Crit Care Med 2004; 169(3):393–398. https://doi. org/10.1164/rccm.200301-055OC
Shaheen SO, Sterne JAC, Thompson RL, Songhurst CE, Margetts BM, Burney PGJ. Dietary antioxidants and asthma in adults: population-based case-control study. Am J Respir Crit Care Med 2001; 164(10):1823-1828. https://doi.org/10.1164/ajrccm.164.10.2104061
Vural H, Uzun K, Uz E, Koc A. Concentrations of copper, zinc and various elements in serum of patients with bronchial asthma. J Trace Elem Med Biol 2000; 14(2):88-91. https://doi.org/10.1016/S0946-672X(00)80036-X
Honscheid A, Rink L, Haase H. T-lymphocytes: a target for stimulatory and inhibitory effects of zinc ions. Endocr Metab Immun Disor Drug Targets 2009; 9(2):132–144. https://doi.org/10.2174/187153009788452390
Tuerk MJ, Fazel N. Zinc deficiency. Current Opinion in Gastroenterology 2009; 25(2):136–143. https://doi. org/10.1097/MOG.0b013e328321b395
Asher MI, Keil U, Anderson HR. International study of asthma and allergies in childhood (ISAAC): rationale and methods. Eur Respir J 1995; 8(3)483– 491. https://doi.org/10.1183/09031936.95.08030483
Seaton A, Godden DJ, Brown K. Increase in asthma: a more toxic environment or a more susceptible population. Thorax 1994; 49: 171-74. https://dx.doi. org/10.1136%2Fthx.49.2.171
Smiyan OI, Loboda AM, Manko YA, Bynda TP, Popov SV, Petrashenko VO, et al. Dynamics of content of some minerals in teenagers with cardiovascular system pathology against the background of chronic tonsillitis. Wiadomosci Lekarskie 2018; LXXI (4): 861-864.
Mettler FA, Jr, Gus’kova AK, Gusev I. Health effects in those with acute radiation sickness from the Chernobyl accident. Health Phys 2007;93:462-469. https://doi.org/10.1097/01.HP.0000278843.27969.74
Prysyazhnyuk AY, Grishtshenko VG, Fedorenko ZP, Gulak LO, Fuzik MM. Review of epidemiological finding in study of medical consequences of the Chernobyl accident in Ukrainian population. In: Imanaka T, editor. Recent Research Activities about the Chernobyl NPP Accident in Belarus, Ukraine and Russia [KURRI-KR-79] Kyoto: Research Reactor Institute, Kyoto University; 2002:188–202. https://dx.doi.org/10.1667%2FRR14791.1
Bennett B, Repacholi M, Carr Z, editors. Health effects of the Chernobyl accident and special health care programmes: Report of the UN Chernobyl Forum Expert Group “Health”. Geneva, Switzerland: World Health Organization; 2006.
Wu LC, Zarrin A A. The production and regulation of IgE by the immune system. Nat Rev Immunol 2014;14: 247–259, https://doi.org/10.1038/nri3632
Gould HJ, et al. The biology of IGE and the basis of allergic disease. Ann Rev Immunol 2003; 21:579–628, https://doi.org/10.1146/annurev.immunol.21.120601.141103
Ober C, Yao TC. The genetics of asthma and allergic disease: a 21st century perspective. Immunol Rev 2011;241:10-30. https://doi.org/10.1111/j.1600-065X.2011.01029.x
Bowler RP, Crapo JD. Oxidative stress in allergic respiratory diseases. J Allergy Clin Immunol 2002;110:349-56. https://doi.org/10.1067/mai.2002.126780
Bakkeheim E, Mowinckel P, Carlsen KH, Burney P, Lødrup Carlsen KC.Altered oxidative state in schoolchildren with asthma and allergic rhinitis. Pediatr Allergy Immunol 2011;22:178-185. https://doi. org/10.1258%2Facb.2011.010266
Kalhan R, Tran BT, Colangelo LA, et al. Systemic inflammation in young adults is associated with abnormal lung function in middle age. PLoS One 2010;5:e11431. https://doi.org/10.1371/journal.pone.0011431
Groen H, Pater JM, Nieuwenhuis P, Rozing J. Elevated intracellular glutathione levels in CD4 þ T cells of BB rats. Transplant Proc 1997;29:1679–80.
Koike Y, Hisada T, Utsugi M, et al. Glutathione redox regulates airway hyperresponsiveness and airway inflammation in mice. Am J Respir Cell Mol Biol 2007;37:322-329. https://doi.org/10.1165/rcmb.2006-0423OC
Shvedova AA, Kisin ER, Murray AR, et al. Vitamin E deficiency enhances pulmonary inflammatory response and oxidative stress induced by single-walled carbon nanotubes in C57BL/6 mice. Toxicol Appl Pharmacol 2007;221:339–48. https://doi.org/10.1016/j. taap.2007.03.018
Comhair SA, Erzurum SC. Redox control of asthma: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal 2010;12:93–124. https://doi. org/10.1089/ars.2008.2425
Oluwole O, Arinola GO, Ana GR. Relationship between household air pollution from biomass smoke exposure, and pulmonary dysfunction, oxidant-antioxidant imbalance and systemic inflammation in rural women and children in Nigeria. Global J Health Sci 2013;5:28- 38.
Malling TH, Sigsgaard T, Andersen HR, et al. Differences in associations between markers of antioxidative defense and asthma are sex specific. Gend Med 2010;7:115 – 24.
Kloek J, Mortaz E, van Ark I, Lilly CM, Nijkamp FP, Folkerts G. Glutathione prevents the early asthmatic reaction and airway hyperresponsiveness in guinea pigs. J Physiol Pharmacol 2010;61:67-72. https://doi. org/10.1016/j.genm.2010.03.004
Perisic´ T, Sreckovic´ M, Matic´ G. An imbalance in antioxidant enzymes and stress proteins in childhood asthma. Clin Biochem 2007;40:1168 – 71.
Murr C, Schroecksnadel K, Winkler C, Ledochowski M, Fuchs D. Antioxidants may increase the probability of developing allergic diseases and asthma. Med Hypotheses 2005;64:973-7. https://doi.org/10.1016/j. mehy.2004.11.011
King MR, Ismail AS, Davis LS, Karp DR. Oxidative stress promotes polarization of human T cell differ-entiation toward a T helper 2 phenotype. J Immunol 2006; 176:2765-2772. https://doi.org/10.4049/jimmu-nol.176.5.2765
Ngoc LP, Gold DR, Tzianabos AO, Weiss ST, Celedon JC. Cytokines, allergy, and asthma. Curr Opin Allergy Clin Immunol 2005;5:161-166. https://doi.org/10.1097/01. all.0000162309.97480.45
Lloyd C, Hessel EM. Functions of T cells in asthma: more than just Th2 cells. Nat Rev 2010;10:838-848. https://doi. org/10.1038/nri2870
Halliwell B. Free radicals and antioxidants: updating a personal view. Nutr Rev 2012;70:257-65. https://doi. org/10.1111/j.1753-4887.2012.00476.x
Chinellato I, Piazza M, Sandri M, Peroni D, Piacentini G, Boner L. Vitamin D serum levels and markers of asthma control in Italian children. J Pediatr 2011; 158 (3):437–441. https://doi.org/10.1016/j.jpeds.2010.08.043
Kankaanpa P, Sutas Y, Salminen S, Lichtenstein A, Isolauri E. Dietary fatty acids and allergy. Ann Med 1999;31 (4):282-287.
Bystrova NA, Konoplya AI, Shushkevich DL, Anokhin AY. Role mikroelementov v biokhimicheskikh protses-sakh. Kursk: KurGMU; 2014; 85 (In Russian).
Picado C, Deulofeu R, Lleonart R, et al. Dietary micronutrients/antioxidants and their relationship with bronchial asthma severity. Allergy 2008;56:43-49. https://doi. org/10.1034/j.1398-9995.2001.00793.x
Michalska-Mosiej M, Socha K, Soroczyńska J, Karpińska E, Łazarczyk B, Borawska MH. Selenium, zinc, copper, and total antioxidant status in the serum of patients with chronic tonsillitis. Biol Trace Elem Res 2016;173:30-34. https://dx.doi.org/10.1007%2Fs12011-016-0634-2
Kocyigit A, Armutcu F, Gurel A, Ermis B. Alterations in plasma essential trace elements selenium, manganese, zinc, copper, and iron concentrations and the possible role of these elements on oxidative status in patients with childhood asthma. Biol Trace Elem Res 2004;97:31-41. https://doi.org/10.1385/BTER:97:1:31
Ochs-Balcom HM, Grant BJ, Muti P, et al. Antioxidants, oxidative stress, and pulmonary function in individuals diagnosed with asthma or COPD. Eur J Clin Nutr 2006;60:991-999 https://doi.org/10.1038/sj.ejcn.1602410
Socha K, Kochanowicz J, Karpińska E, Soroczyńska J, Jakoniuk M, Mariak Z, et al. Dietary habits and selenium, glutathione peroxidase and total antioxidant status in the serum of patients with relapsing-remitting multiple sclerosis, Nutr J 2014;13:62. https://doi.org/10.1186/1475-2891-13-62
Prasad AS. Zinc in human health: effect of zinc on immune cells. Mol Med 2008; 14: 353–357. https://dx.doi.org/10.2119%2F2008-00033.Prasad
Dozor AJ. The role of oxidative stress in the pathogenesis and treatment of asthma. Ann N Y Acad Sci 2010;1203:133-137 https://doi.org/10.1111/j.1749-6632.2010.05562.x
Fujita M, Ueki S, Ito W, et al. C-reactive protein levels in the serum of asthmatic patients. Ann Allergy Asthma Immunol 2007;99:48–53 https://doi.org/10.1016/S1081-1206(10)60620-5
Pokuszyńska K, Brózik H, Sikora JP. The influence of treatment with hypoallergic diet on antioxidative barrier and lipid peroxidation products in children with cow’s milk allergy. Alergia Astma Immunol 2000; 5: 68-73. DOI: 10.5114/aoms.2012.32420
Kalita B, Nowak P, Ślomok M, et al. Selenium plasma concentration level in children with food allergy. Pol Merk Lek 2001; 10: 411-3.
Anke M. Essential and toxic effects of macro, trace and ultratrace elements in the nutrition of man. In: Anke M, Merian E, Ihnat M, Stoeppler M, editors. Elements and Their Compounds in the Environment. Vol. 1. Weinheim: Wiley-VCH; 2004. p. 343-367. https://doi.org/10.1002/ 9783527619634.ch16
Gürgöze MK, Olçücü A, Aygün AD, Taskin E, Kiliç M. Serum and hair levels of zinc, selenium, iron, and copper in children with iron-deficiency anemia. Biol Trace Elem Res 2006;111(1-3):23-29. https://doi.org/10.1385/BTER:111:1:23
Jomova K, Valko M. Advances in metal-induced oxida-tive stress and human disease. Toxicology 2011;10(2-3):65-87. https://doi.org/10.1016/j.tox.2011.03.001
Agbas A, Hui D, Wang X, Tek V, Zaidi A, Michaelis EK. Activation of brain calcineurin (Cn) by Cu-Zn superoxide dismutase (SOD1) depends on direct SOD1-Cn protein interactions occurring in vitro and in vivo. Biochem J 2007;405(1):51-59. https://doi.org/10.1042/BJ20061202
Fukada T, Yamasaki S, Nishida K, Murakami M, Hirano T. Zinc homeostasis and signaling in health and diseases: Zinc signaling. J Biol Inorg Chem 2011;16(7):1123-1134. https://doi.org/10.1007/s00775-011-0797-4
Klein T, Bischoff R. Physiology and pathophysiology of matrix metalloproteases. Amino Acids. 2011;41(2):271-
https://doi.org/10.1007/s00726-010-0689-x
Nair HB, Sung B, Yadav VR, Kannappan R, Chaturvedi MM, Aggarwal BB. Delivery of antiinflammatory nutra-ceuticals by nanoparticles for the prevention and treat-ment of cancer. Biochem Pharmacol 2010;80:1833-1843. https://doi.org/10.1016/j.bcp.2010.07.021
Sprietsma JE. Modern diets and diseases: NO-zinc balance. Under Th1, zinc and nitrogen monoxide (NO) collectively protect against viruses, AIDS, autoimmunity, diabetes, allergies, asthma, infectious diseases, atherosclerosis and cancer. Med Hypotheses 1999;53:6 – 16 https://doi.org/10.1054/mehy.1999.0867
Murgia C, Lang CJ, Truong-Tran AQ, et al. Zinc and its specific transporters as potential targets in airway disease. Curr Drug Targets 2006;7:607–27. https://doi. org/10.2174/138945006776818683
Omata N, Tsukahara H, Ito S, Ohshima Y, Yasutomi M, Yamada A, et al. Increased oxidative stress in childhood atopic dermatitis. Life Sci 2001; 69: 223–228. https://doi.org/10.1016/S0024-3205(01)01124-9
Tsukahara H, Shibata R, Ohshima Y, Todoroki Y, Sato S, Ohta N, et al. Oxidative stress and altered antioxidant defenses in children with acute exacerbation of atopic dermatitis. Life Sci 2003;72: 2509–2516. https://doi. org/10.1016/S0024-3205(03)00145-0
Kocabas CN, Adalioglu G, Cos¸kun T, Tuncer A, Sekerel BE. The relationship between serum selenium levels and frequent wheeze in children. Turk J Pediatr 2006;48:308 –12.
Omland Ø, Deguchi Y, Sigsgaard T, Hansen JC. Selenium serum and urine is associated to mild asthma and atopy. The SUS study. J Trace Elem Med Biol 2002;16:123-127. https://doi.org/10.1016/S0946-672X(02)80039-6
Jacobson GA, Yee KC, Ng CH. Elevated plasma glutathione peroxidase concentration in acute se-vere asthma: comparison with plasma glutathione peroxidase activity, selenium and malondialdehyde. Scand J Clin Lab Invest 2007;67:423-430. https://doi. org/10.1080/00365510601153353
Spee B, Mandigers PJJ, Arends B, et al. Differential expression of copper-associated and oxidative stress related proteins in a new variant of copper toxicosis in Doberman pinschers. Comp Hepatol 2005;4:3 https://doi. org/10.1186/1476-5926-4-3
Hassan AM. Selenium status in patients with aspirin-induced asthma. Ann Clin Biochem 2008;45(Pt 5):508-12. https://doi.org/10.1258/acb.2008.008030
Hawkes WC, Hwang A, Alkan Z. The effect of selenium supplementation on DTH skin responses in healthy North American men. J Trace Elem Med Biol 2009; 23: 272–280. https://doi.org/10.1016/j.jtemb.2009.04.002.
Uzuner N, Karaman O, Coker C, Turgut S, Uzuner H, Onvural B. Serum trace element levels in bronchial asthma.Turk Respir J 2001;2(3):10–15
Arthur JR, McKenzie RC, Beckett GJ. Selenium in the immune system. J Nutrition 2003;33(5):1457S–1459S. https://doi.org/10.1093/jn/133.5.1457S
Jeong DW, Yoo MH, Kim TS, Kim JH, Kim I Y. Protection of mice from allergen-induced asthma by selenite. Prevention of eosinophil infiltration by inhibition of NF--B activation. J Biol Chem 2002;277(20):17871–17876.
Rubin RN, Navon L, Cassano PA. Relationship of serum antioxidants to asthma prevalence in youth. Am J Respir Crit Care Med 2004;169(3):393–398. https://dx.doi. org/10.1164%2Frccm.200502-180OC
Perisic´ T, Srec´ kovic´ M, Matic´ G. An imbalance in antioxidant enzymes and stress proteins in childhood asthma. Clin Biochem 2007;40:1168 – 71.
Malling TH, Sigsgaard T, Andersen HR, et al. Differences in associations between markers of antioxidative defense and asthma are sex specific. Gend Med 2010;7:115 – 24. https://doi.org/10.1016/j.genm.2010.03.004
Kloek J, Mortaz E, van Ark I, Lilly CM, Nijkamp FP, Folkerts G.Glutathione prevents the early asthmatic reaction and airway hyperresponsiveness in guinea pigs. J Physiol Pharmacol 2010;61:67 – 72.
Pokuszyńska K, Brózik H, Sikora JP. The influence of treatment with hypoallergic diet on antioxidative barrier and lipid peroxidation products in children with cow’s milk allergy. Alergia Astma Immunol 2000; 5: 68-73.
Kalita B, Nowak P, Ślomok M, et al. Selenium plasma concentration level in children with food allergy. Pol Merk Lek 2001; 10: 411-3.
Omland Ø, Deguchi Y, Sigsgaard T, Hansen JC. Selenium serum and urine is associated to mild asthma and atopy. The SUS study. J Trace Elem Med Biol 2002;16(2):123–127. https://doi.org/10.1016/S0946-672X(02)80039-6
Rubin RN, Navon L, Cassano PA. Relationship of Serum Antioxidants to Asthma Prevalence in Youth. Am J Respir Crit Care Med 2004;169(3):393-399. https://doi. org/10.1164/rccm.200301-055OC
Devereux G. The increase in the prevalence of asthma and allergy: food for thought. Nat Rev Immunol 2006;6(11):869–874. https://doi.org/10.1038/nri1958
Devereux G., McNeill G., Newman G., Turner S., Craig L., Martindale S., Helms F., Seaton A. Early childhood wheezing symptoms in relation to plasma selenium in pregnant mothers and neonates. Clin Exp Allergy 2007;37(7):1000–1008.
Baız N, Chastang J, Ibanez G, Annesi-Maesano I. Prenatal exposure to selenium may protect against wheezing in children by the age of 3. Immun Inflamm Dis 2017; 5(1): 37–44. https://dx.doi.org/10.1002%2Fiid3.138
Fumitoshi Sakazaki, Tomohiro Arakawa, Ryo Shimizu, Hirofumi Ogino, Tomofumi Okuno & Hitoshi Ueno. Allergies are aggravated by mild selenium deficiency and abrogated by supplementation with selenomethionine, Food Agricult Immunol 2014, 25:4, 477-485. https://doi. org/10.1080/09540105.2013.837866
Bakkeheim E, Mowinckel P, Carlsen KH, Burney P, Carlsen KC. Altered oxidative state in schoolchildren with asthma and allergic rhinitis. Pediatr Allergy Immunol 2011;22(2):178-85.
Vodounon CA, Abramova ZI, Aikou N, Sezan A, Kot-choni SO, Akpona SA. The particularities of protein fraction in the apoptosis of lymphocytes of patients with asthma. Pakistan journal of biological sciences: PJBS 2013;16(24):1873-83. http://dx.doi.org/10.3923/pjbs.2013.1873.1883
Burney P1, Potts J, Makowska J, Kowalski M, Phillips J, Gnatiuc L, at al. A case-control study of the relation between plasma selenium and asthma in European populations: a GAL2EN project. Allergy 2008;63(7):865-871. https://doi.org/10.1111/j.1398-9995.2008.01716.x
Dunstan J. A, Breckler L, Hale J et al. Supplementation with vitamins C, E, β-carotene and selenium has no effect on antioxidant status and immune responses in allergic adults: a randomized controlled trial. Clin Exp Allergy 2007;37(2):180–187. https://doi.org/10.1111/j.1365-2222.2007.02657.x
Zalewski PD. Zinc metabolism in the airway: Basic mechanisms and drug targets. Curr. Opin. Pharmacol. 2006;6:237–243. http://doi.org/10.1016/j. coph.2006.01.005
Childers M, Eckel G, Himmel A, Caldwell J. A new model of cystic fibrosis pathology: Lack of transport of glutathione and its thiocyanate conjugates. Med Hypotheses 2007;68:101–112.
Zsembery A, Fortenberry JA, Liang L, Bebok Z, Tucker TA, Boyce AT, et al. Extracellular zinc and ATP restore chloride secretion across cystic fibrosis airway epithelia by triggering calcium entry. J Biol Chem 2004;279: 10720-10729. https://doi.org/10.1074/jbc.M313391200
Nadeem A, Masood A, Siddiqui N. Oxidant-antioxidant imbalance in asthma: Scientific evidence, epidemiological data and possible therapeutic options. Ther Adv Respir Dis 2008; 2:215–235. https://doi. org/10.1177/1753465808094971
Hönscheid A, Rink L, Haase H. T-lymphocytes: A target for stimulatory and inhibitory effects of zinc ions. Endocr Metab Immune Disord Drug Targets 2009;9:132–144. https://doi.org/10.2174/187153009788452390
Truong-Tran AQ, Ruffin RE, Foster PS, Koskinen AM, Coyle P, Philcox JC, et al. Altered zinc homeostasis and caspase-3 activity in murine allergic airway inflammation. Am J Respir Cell Mol Biol 2002;27:286–296. https://doi. org/10.1165/rcmb.2001-0014OC
Hotz C: The potential to improve zinc status through biofortification of staple food crops with zinc. Food Nutr Bull 2009, 30(1):172–178. https://doi. org/10.1177/15648265090301S109
Hess SY, Brown KH: Impact of zinc fortification on zinc nutrition. Food Nutr Bull 2009, 30(1):79–107. https://doi. org/10.1177/15648265090301S106
Gibson RS, Anderson VP: A review of interventions based on dietary diversification or modification strategies with the potential to enhance intakes of total and absorbable zinc. Food Nutr Bull 2009, 30(1):108–143. https://doi. org/10.1177/15648265090301S107
Hess SY, Lönnerdal B, Hotz C, Rivera JA, Brown KH: Recent advances in knowledge of zinc nutrition and human health. In: International Zinc Nutrition Consultative Group Technical Document No 2 Systematic Reviews of Zinc Intervention Strategies. Brown KH and Hess SY, edi-tors; 2009. https://doi.org/10.1177/15648265090301S102
IZiNCG: Assessment of the risk of zinc deficiency in populations and options for its control. Food Nutr Bull 2004, 25:91–204.
Caulfield L, Black R: Zinc deficiency. In Comparative quantification of health risks: Global and regional burden of disease attributable to select major risk factors. Edited by Ezzati M, Lopez A, Rodgers A, Murray C. Geneva: World Health Organization; 2004.
WHO: Clinical management of acute diarrhoea. Geneva/New York: World Health Organization/UNICEF; 2004. Fink and Heitner BMC Public Health 2014, 14:852 Page 8 of 10 http://www.biomedcentral.com/1471-2458/14/8525. WHO: Implementing the new recommendations of the clinical management of diarrhoea. Geneva: World Health Organization; 2006.
Kocyigit A, Armutcu F, Gurel A, Ermis B. Alterations in plasma essential trace elements selenium, manganese, zinc, copper, and iron concentrations and the possible role of these elements on oxidative status in patients with childhood asthma. Biol Trace Elem Res 2004;97(1):31-41 https://doi.org/10.1385/BTER:97:1:31
Vural H, Uzun K, Uz E, Kocyigit A, Cigli A, Akyol O. Concentrations of copper, zinc and various elements in serum of patients with bronchial asthma. J Trace Elem Med Biol 2000;14(2):88-91. https://doi.org/10.1016/S0946-672X(00)80036-X
Guo CH, Liu PJ, Hsia S, Chuang CJ, Chen PC. Role of certain trace minerals in oxidative stress, inflammation, CD4/CD8 lymphocyte ratios and lung function in asthmatic patients. Ann Clin Biochem 2011;48(Pt 4):344-51. https://doi.org/10.1258/acb.2011.010266
Razi CH, Akelma AZ, Akin O, et al. Hair zinc and selenium levels in children with recurrent wheezing. Pediatr Pulmonol 2012;47:1185-91. https://doi.org/10.1002/ppul.22628
Khanbabaee G, Omidian A, Imanzadeh F, Adibeshgh F, Ashayeripanah M, Rezaei N. Serum level of zinc in asthmatic patients: a case-control study. Allergol Immunopathol 2014; 42(1):19-21. https://doi.org/10.1016/j. aller.2012.07.008
Zeidan A, AbdulWahab A, Avades T, Chandra P. Serum zinc level in asthmatic and healthy school children. Eur Respir J 2015; 46: PA3651. DOI:10.1183/13993003.congress-2015. PA3651.
Arik Yilmaz E, Ozmen S, Bostanci I, Misirlioglu ED, Ertan U. Erythrocyte zinc levels in children with bronchial asthma. Pediatr Pulmonol 2011; 46: 1189-1193.
Toyran, M, et al. Trace element levels in children with atopic dermatitis. J Invest Allergol Clin Immunol 2012;22:341-344.
David TJ, Wells FE, Sharpe TC, Gibbs AC, Devlin J. Serum levels of trace metals in children with atopic eczema. Br J Dermatol 1990; 122: 485-489. https://doi. org/10.1111/j.1365-2133.1984.tb06630.x
Takahashi H, et al. Effects of zinc deficient diet on development of atopic dermatitis-like eruptions in DS-Nh mice. J Dermatol Sci 2008;50: 31-39, DOI:10.1016/j. jdermsci.2007.11.002
Fink G, Heitner J. Evaluating the cost-effectiveness of preventive zinc supplementation. BMC Public Health 2014; 14:852. DOI:10.1186/1471-2458-14-852
Rerksuppaphol S, Rerksuppaphol L. Zinc supplementation in children with asthma exacerbation. Pediatr Rep 2016; 8:6685, 63-67. DOI:10.4081/pr.2016.6685
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