Transcription factors are key regulators of cell fate maintenance and transition. Thus, they represent key molecular targets in the fields of stem cell biology and regenerative medicine. The constant need to generate protocols with higher stem cell yield, faster and more efficient differentiation led to in-depth understanding of the function of many transcription factors in regulating developmental and adult stem cells. In this Dance Round we summarize the current understanding of the expression of a zinc finger and BTB domain-containing transcription factor ZBTB20, and comment on how its expression provides clues for its involvement in stem cell biology.
Youn YH, Wynshaw-Boris A. A new way of looking at neurogenesis at the apical surface. EMBO Rep 2009; 10: 457–458. DOI:10.1038/embor.2009.71
Kosodo Y, Röper K, Haubensak W, Marzesco A-M, Corbeil D, Huttner WB. Asymmetric distribution of the apical plasma membrane during neurogenic divisions of mammalian neuroepithelial cells. EMBO J 2004; 23: 2314–2324
Petros TJ, Bultje RS, Ross ME, Fishell G, Anderson SA. Apical versus basal neurogenesis directs cortical interneuron subclass fate. Cell Rep 2015; 13: 1090–1095
Paridaen JTML, Wilsch-Bräuninger M, Huttner WB. Asymmetric Inheritance of Centrosome-Associated Primary Cilium Membrane Directs Ciliogenesis after Cell Division. Cell 2013; 155: 333–344. DOI:10.1016/j. cell.2013.08.060
Chenn A, McConnell SK. Cleavage orientation and the asymmetric inheritance of notchl immunoreactivity in mammalian neurogenesis. Cell 1995; 82: 631–641. DOI:10.1016/0092-8674(95)90035-7
Lindvall O, Kokaia Z. Neurogenesis following Stroke Affecting the Adult Brain. Cold Spring Harb Perspect Biol 2015; 7: a019034. DOI:10.1101/cshperspect.a019034
Rodgers JT, King KY, Brett JO, Cromie MJ, Charville GW, Maguire KK, et al. mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert. Nature 2014; 510: 393–6. DOI:10.1038/nature13255
Courties G, Herisson F, Sager HB, Heidt T, Ye Y, Wei Y, et al. Ischemic Stroke Activates Hematopoietic Bone Marrow Stem Cells. Circ Res 2015; 116: 407–417. DOI:10.1161/CIRCRESAHA.116.305207
Halbeisen RE, Galgano A, Scherrer T, Gerber AP. Post-transcriptional gene regulation: From genome-wide stud-ies to principles. Cell Mol Life Sci 2008; 65: 798–813. DOI:10.1007/s00018-007-7447-6
Gibcus J, Dekker J. The context of gene expression regulation. F1000 Biol Rep 2012; 4: ??? DOI:10.3410/B4-8
Jansen M, Moor CHD, Sussenbach JS. Translational Control of Gene Expression. : 6 ????
Mann M, Jensen ON. Proteomic analysis of post-translational modifications. Nat Biotechnol 2003; 21: 255–61. DOI[10.1038/nbt0303-255]
Doi D, Magotani H, Kikuchi T, Ikeda M, Hiramatsu S, Yoshida K, et al. Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease. Nat Commun 2020; 11: 3369. DOI[10.1038/s41467-020-17165-w]
Rowe RG, Daley GQ. Induced pluripotent stem cells in disease modelling and drug discovery. Nat Rev Genet 2019; 20: 377–88. DOI[10.1038/s41576-019-0100-z]
Shi Y, Inoue H, Wu JC, Yamanaka S. Induced pluripotent stem cell technology: a decade of progress. Nat Rev Drug Discov 2017; 16: 115–30. DOI[10.1038/nrd.2016.245]
Mitchelmore C, Kjærulff KM, Pedersen HC, Nielsen JV, Rasmussen TE, Fisker MF, et al. Characterization of Two Novel Nuclear BTB/POZ Domain Zinc Finger Isoforms: ASSOCIATION WITH DIFFERENTIATION OF HIPPOCAMPAL NEURONS, CEREBELLAR GRANULE CELLS, AND MACROGLIA. J Biol Chem 2002; 277: 7598–609. DOI[10.1074/jbc.M110023200]
Stogios PJ, Downs GS, Jauhal JJ, Nandra SK, Privé GG. Sequence and structural analysis of BTB domain proteins. Genome Biol 2005; 6: R82. DOI[10.1186/gb-2005-6-10-r82]
Laity JH, Lee BM, Wright PE. Zinc finger proteins: new insights into structural and functional diversity. Curr Opin Struct Biol 2001; 11: 39–46. DOI[10.1016/S0959-440X(00)00167-6]
Zhang W, Mi J, Li N, Sui L, Wan T, Zhang J, et al. Identification and Characterization of DPZF, a Novel Human BTB/POZ Zinc Finger Protein Sharing Homology to BCL-6. Biochem Biophys Res Commun 2001; 282: 1067–73. DOI[10.1006/bbrc.2001.4689]
Urbán N, Guillemot F. Neurogenesis in the embryonic and adult brain: same regulators, different roles. Front Cell Neurosci 2014; 8. DOI[10.3389/fncel.2014.00396]
Rosenthal EH, Tonchev AB, Stoykova A, Chowdhury K. Regulation of archicortical arealization by the transcription factor Zbtb20. Hippocampus 2012; 22: 2144–56
Tonchev AB, Tuoc TC, Rosenthal EH, Studer M, Stoykova A. Zbtb20 modulates the sequential generation of neuronal layers in developing cortex. Mol Brain 2016; 9: 1
Xie Z, Ma X, Ji W, Zhou G, Lu Y, Xiang Z, et al. Zbtb20 is essential for the specification of CA1 field identity in the developing hippocampus. Proc Nat Acad Sci USA 2010; 107: 6510–5. DOI:10.1073/pnas.0912315107
Nielsen JV, Blom JB, Noraberg J, Jensen NA. Zbtb20-Induced CA1 Pyramidal Neuron Development and Area Enlargement in the Cerebral Midline Cortex of Mice. Cerebral Cortex 2010; 20: 1904–14. DOI[10.1093/cercor/bhp261]
Nagao M, Ogata T, Sawada Y, Gotoh Y. Zbtb20 promotes astrocytogenesis during neocortical development. Nat Commun 2016; 7: 11102. DOI[10.1038/ncomms11102]
Doeppner TR, Herz J, Bähr M, Tonchev AB, Stoykova A. Zbtb20 Regulates Developmental Neurogenesis in the Olfactory Bulb and Gliogenesis After Adult Brain Injury. Mol Neurobiol 2019; 56: 567–82. DOI[10.1007/s12035-018-1104-y]
Nielsen JV, Thomassen M, Møllgård K, Noraberg J, Jensen NA. Zbtb20 Defines a Hippocampal Neuronal Identity Through Direct Repression of Genes That Control Projection Neuron Development in the Isocortex. Cerebral Cortex 2014; 24: 1216–29. DOI[10.1093/cercor/bhs400]
Qu Z, Zhang H, Huang M, Shi G, Liu Z, Xie P, et al. Loss of ZBTB20 impairs circadian output and leads to unimodal behavioral rhythms. eLife 2016; 5: e17171. DOI[10.7554/eLife.17171]
Legué E, Gottshall JL, Jaumouillé E, Roselló-Díez A, Shi W, Barraza LH, et al. Differential timing of granule cell production during cerebellum development underlies generation of the foliation pattern. Neural Dev 2016; 11: 17. DOI[10.1186/s13064-016-0072-z]
Ren A-J, Wang K, Zhang H, Liu A, Ma X, Liang Q, et al. ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons. Nat Commun 2014; 5: 4984. DOI[10.1038/ncomms5984]
Kardon G. Development of the musculoskeletal system: meeting the neighbors. Development 2011; 138: 2855–9. DOI[10.1242/dev.067181]
Alonso-Martin S, Rochat A, Mademtzoglou D, Morais J, de Reyniès A, Auradé F, et al. Gene Expression Profiling of Muscle Stem Cells Identifies Novel Regulators of Postnatal Myogenesis. Front Cell Dev Biol 2016; 4. DOI[10.3389/fcell.2016.00058]
Zhou G, Jiang X, Zhang H, Lu Y, Liu A, Ma X, et al. Zbtb20 regulates the terminal differentiation of hypertrophic chondrocytes via repression of Sox9. Development 2015; 142: 385–93. DOI[10.1242/dev.108530]
Xie Z, Zhang H, Tsai W, Zhang Y, Du Y, Zhong J, et al. Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver. Proc Nat Acad Sci USA 2008; 105: 10859–64. DOI:10.1073/pnas.0800647105
Mesin L, Ersching J, Victora GD. Germinal Center B Cell Dynamics. Immunity 2016; 45: 471–82. DOI:10.1016/j. immuni.2016.09.001
Chevrier S, Emslie D, Shi W, Kratina T, Wellard C, Karnowski A, et al. The BTB-ZF transcription factor Zbtb20 is driven by Irf4 to promote plasma cell differentiation and longevity. J Exp Med 2014; 211: 827–40. DOI[10.1084/jem.20131831]
Wang Y, Bhattacharya D. Adjuvant-specific regulation of long-term antibody responses by ZBTB20. J Exp Med 2014; 211: 841–56. DOI[10.1084/jem.20131821]
Sun Y, Preiss NK, Valenteros KB, Kamal Y, Usherwood Y-K, Frost HR, et al. Zbtb20 Restrains CD8 T Cell Immunometabolism and Restricts Memory Differentiation and Antitumor Immunity. J Immun 2020; 205: 2649–66. DOI[10.4049/jimmunol.2000459]
Dong Q, Chen XY, Li GM. Effect of transcription factor ZBTB20 on mouse pituitary development. Genet Mol Res 2015; 14: 17622–9. DOI[10.4238/2015.December.21.35]
Cao D, Ma X, Cai J, Luan J, Liu A-J, Yang R, et al. ZBTB20 is required for anterior pituitary development and lactotrope specification. Nat Commun 2016; 7: 11121. DOI[10.1038/ncomms11121]
Jiang X, Zhang H, Yin S, Zhang Y, Yang W, Zheng W, et al. Specific deficiency of Plzf paralog, Zbtb20, in Sertoli cells does not affect spermatogenesis and fertility in mice. Sci Rep 2015; 4: 7062. DOI[10.1038/srep07062]
Gu S, Ran S, Qin F, Cao D, Wang J, Liu B, et al. Human Dental Pulp Stem Cells via the NF-κB Path-way. Cell Physiol Biochem 2015; 36: 1725–1734. DOI[10.1159/000430145]
Costoya JA. Functional analysis of the role of POK transcriptional repressors. Brief Funct Genom Proteom 2007; 6: 8–18. DOI:10.1093/bfgp/elm002
Zhang H, Shi J-H, Jiang H, Wang K, Lu J-Y, Jiang X, et al. ZBTB20 regulates EGFR expression and hepatocyte proliferation in mouse liver regeneration. Cell Death Dis 2018; 9: 462. DOI[10.1038/s41419-018-0514-0]
Weng M-Z, Zhuang P-Y, Hei Z-Y, Lin P-Y, Chen Z-S, Liu Y-B, et al. ZBTB20 is involved in liver regeneration after partial hepatectomy in mouse. Hepatobil Pancr Dis Int 2014; 13: 48–54. DOI:10.1016/S1499-3872(14)60006-0
Masaki Kato SM, Natsuko Shinmen NS. Inhibition of Cell Growth by Nuclear Receptor COUP-TFI: Possible Involvement of Decorin in Growth Inhibition. Biochem Physiol 2015; s4. DOI:10.4172/2168-9652.S4-001
Zhao J, Ren K, Tang J. Zinc finger protein ZBTB20 promotes cell proliferation in non-small cell lung cancer through repression of FoxO1. FEBS Lett 2014; 588: 4536–4542. DOI:10.1016/j.febslet.2014.10.005
Schmidt M, Fernandez de Mattos S, van der Horst A, Klompmaker R, Kops GJPL, Lam EW-F, et al. Cell Cycle Inhibition by FoxO Forkhead Transcription Factors Involves Downregulation of Cyclin D. Mol Cell Biol 2002; 22: 7842–52. DOI:10.1128/MCB.22.22.7842-7852.2002
Email this article (Login required) 
