Yi X, Mroczko M, Manoj KM, Wang X, Hager LP. Replacement of the proximal heme thiolate li- gand in chloroperoxidase with a histidine residue. Proc Natl Acad Sci USA 1999;96(22):12412-7. doi: 10.1073/pnas.96.22.12412. PMID: 10535936; PMCID: PMC22935.
Manoj KM, Yi X, Rai GP, Hager LP. A kinetic epoxidation assay for chloroperoxidase. Biochem Biophys Res Commun. 1999;266(2):301-3. doi: 10.1006/bbrc.1999.1810. PMID: 10600497.
Manoj KM, Lakner FJ, Hager LP. Epoxidation of indene by chloroperoxidase. J Mol Catalysis B: Enzymatic 2000; 107-111.DOI: 10.1016/S1381-1177(99)00118-6
Manoj KM, Hager LP. Utilization of peroxide and its relevance in oxygen insertion reactions catalyzed by chloroperoxidase. Biochim Biophys Acta. 2001;1547(2):408- 417. doi: 10.1016/s0167-4838(01)00210-2. PMID: 11410297.
Manoj KM, Hager LP The catalytic utility and versatility of chloroperoxidase. Invited book chapter in Recent Research Developments in Organic Chemistry 2002:6, 393. Transworld Research Network. ISBN:81-7895- 041-3.
Wang X, Tachikawa H, Yi X, Manoj KM, Hager LP. Two- dimensional NMR study of the heme active site structure of chloroperoxidase. J Biol Chem 2003;278(10):7765-74. doi: 10.1074/jbc.M209462200. Epub 2002 Dec 16. PMID: 12488315.
Manoj KM, Hager LP. A colorimetric method for detection and quantification of chlorinating activity of hemeperoxidases. Anal Biochem 2006;348(1):84-6. doi: 10.1016/j.ab.2005.10.014. Epub 2005 Oct 26. PMID: 16289436.
Manoj KM. Chlorinations catalyzed by chloroperoxidase occur via diffusible intermediate (s) and the reaction components play multiple roles in the overall process. Biochem Biophys Acta (BBA)-Proteins & Proteomics 2006; 1764, 1325-1339. DOI: 10.1016/j. bbapap.2006.05.012
Manoj KM Hager LP. Chloroperoxidase, a Janus enzyme. Biochemistry 2008; 47, 2997-3003. DOI: 10.1021/ bi7022656
Manoj KM, Baburaj A, Ephraim B, Pappachan F, Maviliparambathu PP, Vijayan UK, et al. Explaining the atypical reaction profiles of heme enzymes with a novel mechanistic hypothesis and kinetic treat- ment. PLoS One 2010; 17;5(5):e10601. doi: 10.1371/ journal.pone.0010601. PMID: 20498847; PMCID: PMC2871781.
Manoj KM, Gade SK, Mathew L. Cytochrome P450 reductase: a harbinger of diffusible reduced oxygen species. PLoS One 2010;5(10):e13272. doi: 10.1371/ journal.pone.0013272. PMID: 20967245; PMCID: PMC2954143.
Andrew D, Hager L, Manoj KM. The intriguing enhancement of chloroperoxidase mediated one-electron oxidations by azide, a known active-site ligand. Biochem Biophys Res Commun 2011;415(4):646-9. doi: 10.1016/j. bbrc.2011.10.128. Epub 2011 Nov 3. PMID: 22079633.
Parashar A, Manoj KM. Traces of certain drug molecules can enhance heme-enzyme catalytic outcomes. Biochem Biophys Res Commun 2012;417(3):1041-5. doi: 10.1016/j.bbrc.2011.12.090. Epub 2011 Dec 26. PMID: 22214932.
Gideon DA, Kumari R, Lynn AM, Manoj KM. What is the Functional Role of N-terminal Transmembrane Helices in the Metabolism Mediated by Liver Microsomal Cy- tochrome P450 and its Reductase? Cell Biochem Biophys 2012. doi: 10.1007/s12013-012-9339-0. Epub ahead of print. PMID: 22302675.
Gade SK, Bhattacharya S, Manoj KM. Redox active molecules cytochrome c and vitamin C enhance heme-enzyme peroxidations by serving as non-specific agents for redox relay. Biochem Biophys Res Commun 2012;419(2):211-4. doi: 10.1016/j.bbrc.2012.01.149. Epub 2012 Feb 9. PMID: 22342667.
Parashar A, Gade SK, Potnuru M, Madhavan N, Manoj KM. The curious case of benzbromarone: insight into super-inhibition of cytochrome P450. PLoS One 2014;9(3):e89967. doi: 10.1371/journal.pone.0089967. PMID: 24594849; PMCID: PMC3940698.
Parashar A, Venkatachalam A, Gideon DA, Manoj KM. Cyanide does more to inhibit heme enzymes, than merely serving as an active-site ligand. Biochem Biophys Res Commun 2014;455(3-4):190-3. doi: 10.1016/j.bbrc.2014.10.137. Epub 2014 Nov 6. PMID: 25449264.
Manoj KM, Venkatachalam A, Parashar P. Metabolism of xenobiotics by cytochrome P450: novel insights into the thermodynamics, kinetics and roles of redox proteins and diffusible reactive species. Drug Metab Rev 2016; 48: 41-42. DOI: 10.1080/03602532.2016.1191843
Manoj KM, Gade SK, Venkatachalam A, Gideon DA. Electron transfer amongst flavo- and hemo-proteins: diffusible species effect the relay processes, not protein–protein binding. RSC Advances 2016; 6: 24121-24129.
Venkatachalam A, Parashar A, Manoj KM. Functioning of drug-metabolizing microsomal cytochrome P450s: In silico probing of proteins suggests that the distal heme
‚active site‘ pocket plays a relatively ‚passive role‘ in some enzyme-substrate interactions. In Silico Pharmacol 2016;4(1):2. doi: 10.1186/s40203-016-0016-7. Epub
Feb 19. PMID: 26894412; PMCID: PMC4760962
Manoj KM, Parashar A, Venkatachalam A, Goyal S, Satyalipsu, Singh PG, et al. Atypical profiles and modulations of heme-enzymes catalyzed outcomes by low amounts of diverse additives suggest diffusible radicals‘ obligatory involvement in such redox reactions. Biochimie 2016;125:91-111. doi: 10.1016/j.biochi.2016.03.003. Epub 2016 Mar 10. PMID: 26969799.
Manoj KM, Parashar A, Gade SK, Venkatachalam A. Functioning of Microsomal Cytochrome P450s: Mur- burn Concept Explains the Metabolism of Xenobiotics in Hepatocytes. Front Pharmacol. 2016;7:161. doi: 10.3389/fphar.2016.00161. PMID: 27445805; PMCID: PMC4918403.
Manoj KM. Debunking chemiosmosis and proposing murburn concept as the operative principle for cellular respiration. Biomed Rev 2017, 28, 31-48. DOI: 10.14748/ bmr.v28.4450
Parashar A, Gideon DA, Manoj KM. Murburn Concept: A Molecular Explanation for Hormetic and Idiosyncratic Dose Responses. Dose Response 2018;16(2):1559325 818774421. doi: 10.1177/1559325818774421. PMID: 29770107; PMCID: PMC5946624.
Manoj KM. Aerobic Respiration: Criticism of the Protoncentric Explanation Involving Rotary Adeno- sine Triphosphate Synthesis, Chemiosmosis Principle, Proton Pumps and Electron Transport Chain. Biochem Insights 2018b;11:1178626418818442. doi: 10.1177/1178626418818442. PMID: 30643418; PMCID: PMC6311555.
Manoj KM. The ubiquitous biochemical logic of murburn concept. Biomed Rev 2018; 29: 89-97. DOI: 10.14748/bmr. v29.5854
Manoj KM, Gideon DA, Jacob VD. Murburn scheme for mitochondrial thermogenesis. Biomed Rev 2018; 29: 73- 82. DOI: 10.14748/bmr.v29.5852
Gideon DA, Jacob VD, Manoj KM. 2020: murburn concept heralds a new era in cellular bioenergetics. Biomed Rev 2019; 30:89-98. DOI: 10.14748/bmr.v30.6390
Manoj KM. Torday’s prognosis for aging and mortality: more evolution and better life! Biomed Rev 2019, 30, 23-24. DOI: 10.14748/bmr.v30.6384
Jacob VD, Manoj KM. Are adipocytes and ROS villains, or are they protagonists in the drama of life? The murburn perspective. Adipobiology 2019, 10, 7-16. DOI: 10.14748/ adipo.v10.6534
Manoj KM, Parashar A, David Jacob V, Ramasamy S. Aero- bic respiration: proof of concept for the oxygen-centric mur- burn perspective. J Biomol Struct Dyn. 2019;37(17):4542-4556. doi: 10.1080/07391102.2018.1552896. Epub 2019 Jan 8. PMID: 30488771.
Manoj KM, Soman V, David Jacob V, Parashar A, Gideon DA, Kumar M, et al. Chemiosmotic and murburn explanations for aerobic respiration: Predictive capabilities, structure-function correlations and chemico-physical logic. Arch Biochem Biophys 2019;676:108128. doi: 10.1016/j. abb.2019.108128. Epub 2019 Oct 14. PMID: 31622585.
Manoj KM. Refutation of the cation-centric torsional ATP synthesis model and advocating murburn scheme for mitochondrial oxidative phosphorylation. Biophys Chem. 2020a;257:106278. doi: 10.1016/j.bpc.2019.106278. Epub 2019 Nov 18. PMID: 31767207.
Manoj KM. Murburn concept: a paradigm shift in cellular metabolism and physiology. Biomol Concepts 2020b;11(1):7-22. doi: 10.1515/bmc-2020-0002. PMID: 31961793.
Manoj KM, Soman V. Classical and murburn explanations for acute toxicity of cyanide in aerobic respiration: A personal perspective. Toxicology 2020;432:152369. doi:
1016/j.tox.2020.152369. Epub 2020 Jan 30. PMID:
Manoj KM, Ramasamy S, Parashar A, Gideon DA, Soman V, Jacob VD, Pakshirajan K. Acute toxicity of cyanide in aerobic respiration: Theoretical and experimental support for murburn explanation. Biomol Concepts 2020;11(1):32-56. doi: 10.1515/bmc-2020-0004. PMID: 32187011.
Manoj KM, Jacob VD. Murburn precepts for photoreception. Biomd Rev 2020, 31:67-74. doi: 10.14748/bmr. v31.7706
Manoj KM. In defense of the murburn explanation for aerobic respiration. Biomed Rev 2020, 31:135-160. DOI: 10.14748/bmr.v31.7713. Also refer the Supplementary Information in the issue. DOI: 10.14748/bmr. v31.7714
Manoj KM, Manekkathodi A. Light‘s interaction with pigments in chloroplasts: The murburn perspective. J Photochem Photobiol 2021, 5: 100015. doi: 10.1080/07391102.2020.1835715
Manoj KM, Gideon DA, Parashar A. What is the Role of Lipid Membrane-embedded Quinones in Mitochondria and Chloroplasts? Chemiosmotic Q-cycle versus Murburn Reaction Perspective. Cell Biochem Biophys. 2021;79(1):3-10. doi: 10.1007/s12013-020-00945-y. Epub 2020 Sep 29. PMID: 32989571.
Gideon DA, Nirusimhan V, Manoj KM. Are plastocyanin and ferredoxin specific electron carriers or generic redox capacitors? Classical and murburn perspectives on two photosynthetic proteins. J Biomol Struct Dyn. 2022;40(5):1995-2009. doi: 10.1080/07391102.2020.1835715. Epub 2020 Oct 19. PMID: 33073701.
Parashar A, Manoj KM. Murburn Precepts for Cytochrome P450 Mediated Drug/Xenobiotic Metabolism and Homeostasis. Curr Drug Metab. 2021;22(4):315-326. doi: 10.2174/1389200222666210118102230. PMID: 33461459.
Parashar A, Jacob VD, Gideon DA, Manoj KM. Hemo- globin catalyzes ATP-synthesis in human erythrocytes: a murburn model. J Biomol Struct Dyn. 2021:1-13. doi: 10.1080/07391102.2021.1925592. Epub ahead of print. PMID: 33998971.
Gideon DA, Nirusimhan V, E JC, Sudarsha K, Manoj KM. Mechanism of electron transfers mediated by cytochromes c and b5 in mitochondria and endoplasmic reticulum: classical and murburn perspectives. J Biomol Struct Dyn. 2021; 17:1-18. doi: 10.1080/07391102.2021.1925154. Epub ahead of print. PMID: 33998974.
Manoj KM, Bazhin NM. The murburn precepts for aerobic respiration and redox homeostasis. Prog Biophys Mol Biol. 2021;167:104-120. doi: 10.1016/j. pbiomolbio.2021.05.010. Epub 2021 Jun 10. PMID: 34118265.
Manoj KM, Bazhin NM, Jacob VD, Parashar A, Gideon DA, Manekkathodi A. Structure-function correlations and system dynamics in oxygenic photosynthesis: classical perspectives and murburn precepts. J Biomol Struct Dyn. 2021; 29:1-27. doi: 10.1080/07391102.2021.1953606. Epub ahead of print. PMID: 34323659.
Manoj KM, Gideon DA, Parashar A, Nirusimhan V, Annadurai P, Jacob VD, et al. Validating the predictions of murburn model for oxygenic photosynthesis: Analyses of ligand-binding to protein complexes and cross-system comparisons. J Biomol Struct Dyn. 2021; 30:1-33. doi: 10.1080/07391102.2021.1953607. Epub ahead of print. PMID: 34328391.
Manoj KM, Bazhin N, Tamagawa H. The murburn precepts for cellular ionic homeostasis and electrophysiology. J Cell Physiol. 2022;237(1):804-814. doi: 10.1002/ jcp.30547. Epub 2021 Aug 11. PMID: 34378795.
Manoj KM, Bazhin N, Wu Y, Manekkathodi A. Murburn model of photosynthesis: Effect of additives like chloride and bicarbonate. In: Chlorophylls (2022). ISBN 978-1-80355-487-7. Edited by Ameen S. et al., Intech Open. DOI: 10.5772/intechopen.103132.
Manoj KM, Tamagawa H. Critical analysis of explana- tions for cellular homeostasis and electrophysiology from murburn perspective. J Cell Physiol. 2022;237(1):421-435. doi: 10.1002/jcp.30578. Epub 2021 Sep 13. PMID: 34515340.
Manoj KM, Gideon DA, Jaeken L. Why do cells need oxygen? Insights from mitochondrial composition and function. Cell Biol Int. 2022;46(3):344-358. doi: 10.1002/ cbin.11746. Epub 2021 Dec 28. PMID: 34918410.
Gideon DA, Parashar A, Robin J, Annadurai P, Nirusimhan V, Manoj KM. Do cyclooxygenases possess a murzyme activity? Biomed Rev 2021. 32:47-59. DOI: 10.14748/bmr.v32.8503
Manoj KM, Nirusimhan V, Parashar A, Edward J, Gideon DA. Murburn precepts for lactic-acidosis, Cori cycle, and Warburg effect: Interactive dynamics of dehydrogenases, protons, and oxygen. J Cell Physiol. 2022;237(3):1902- 1922. doi: 10.1002/jcp.30661. Epub 2021 Dec 20. PMID: 34927737.
Manoj KM, Gideon DA, Jaeken L. Interaction of membrane-embedded cytochrome b-complexes with quinols: Classical Q-cycle and murburn model. Cell Biochem Funct. 2022;40(2):118-126. doi: 10.1002/cbf.3682. Epub 2022 Jan 13. PMID: 35026863.
Manoj KM, Bazhin NM, Tamagawa H, Jaeken L, Parashar
A. The physiological role of complex V in ATP synthesis: Murzyme functioning is viable whereas rotary conformation change model is untenable. J Biomol Struct Dyn. 2022; 8:1-20. doi: 10.1080/07391102.2022.2060307. Epub ahead of print. PMID: 35394896.
Manoj KM, Tamagawa H, Bazhin N, Jaeken L, Nirusimhan V, Faraci F, Gideon DA. Murburn model of vision: Precepts and proof of concept. J Cell Physiol. 2022 Aug;237(8):3338-3355. doi: 10.1002/jcp.30786. Epub 2022 Jun 6. PMID: 35662017.
Manoj KM, Gideon DA. Structural foundations for explaining the physiological roles of murzymes embedded in diverse phospholipid membranes. Biochim Biophys Acta Biomembr. 2022;1864(10):183981. doi: 10.1016/j. bbamem.2022.183981. Epub 2022 Jun 8. PMID: 35690100.
Manoj KM, Manekkathodi A, Bazhin N, Parashar A, Wu Y. Comprehensive analyses of enhancement of oxygenesis in photosynthesis by bicarbonate and effects of diverse additives: Classical explanation versus murburn model. In: New Advances in Photosynthesis (2022). ISBN 978-1-83768-427-4. Edited by Kimatu JS. Intech Open. DOI: 10.5772/intechopen.106996
Manoj KM, Gideon DA, Bazhin NM, Tamagawa H, Nirusimhan V, Kavdia M, Jaeken L. Na,K-ATPase: A murzyme facilitating thermodynamic equilibriums at the membrane-interface. J Cell Physiol 2022. doi: 10.1002/ jcp.30925
Manoj KM, Jacob VD, Kavdia M, Tamagawa H, Jaeken L, Soman V. Questioning physiological rotary functionality in the bacterial flagellar system and proposing a murburn model for motility. OSF Preprints 2022. October 25. doi: 10.31219/osf.io/p9wua
Manoj KM. Murburn modifications of proteins. OSF Preprints 2022. December 28. doi: 10.31219/osf.io/ p6k3z
Manoj KM, Jaeken L. Synthesis of Theories on Cellular Powering, Coherence, Homeostasis and Electromechanics: Murburn Concept & Evolutionary Perspectives. OSF Preprints 2022. doi:10.31219/osf.io/56suw.
Gideon DA, Robin J, Annadurai P, Manoj KM. Cyclooxygenase is a Janus murzyme. OSF Preprints 2022.
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